ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

Dominick A. Matos; Jia Min Zhang; Jian Ouyang; Hai Dang Nguyen; Marie Michelle Genois; Lee Zou

doi:10.1016/j.molcel.2019.10.010

ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

Dominick A. Matos, Jia Min Zhang, Jian Ouyang, Hai Dang Nguyen, Marie Michelle Genois, Lee Zou

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

R loops cause genomic instability, but how cells respond to R loop-associated genomic stress is poorly understood. Matos et al. show that the ATR-Chk1 pathway senses R loop-impeded replication forks through a MUS81-mediated mechanism and protects replication forks from excessive MUS81 cleavage, revealing a MUS81-triggered and ATR-mediated feedback loop safeguarding the genome against R loops.

Original language	English (US)
Pages (from-to)	514-527.e4
Journal	Molecular Cell
Volume	77
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2019.10.010
State	Published - Feb 6 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

ATR
Chk1
Fork reversal
Genomic Instability
MUS81
R loop
checkpoint

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/j.molcel.2019.10.010

OpenUrl availability

Full text

Cite this

@article{0ca2b6498a6e4fb99c49ffdaf1084b0f,

title = "ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop",

abstract = "R loops cause genomic instability, but how cells respond to R loop-associated genomic stress is poorly understood. Matos et al. show that the ATR-Chk1 pathway senses R loop-impeded replication forks through a MUS81-mediated mechanism and protects replication forks from excessive MUS81 cleavage, revealing a MUS81-triggered and ATR-mediated feedback loop safeguarding the genome against R loops.",

keywords = "ATR, Chk1, Fork reversal, Genomic Instability, MUS81, R loop, checkpoint",

author = "Matos, {Dominick A.} and Zhang, {Jia Min} and Jian Ouyang and Nguyen, {Hai Dang} and Genois, {Marie Michelle} and Lee Zou",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = feb,

day = "6",

doi = "10.1016/j.molcel.2019.10.010",

language = "English (US)",

volume = "77",

pages = "514--527.e4",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

AU - Matos, Dominick A.

AU - Zhang, Jia Min

AU - Ouyang, Jian

AU - Nguyen, Hai Dang

AU - Genois, Marie Michelle

AU - Zou, Lee

PY - 2020/2/6

Y1 - 2020/2/6

N2 - R loops cause genomic instability, but how cells respond to R loop-associated genomic stress is poorly understood. Matos et al. show that the ATR-Chk1 pathway senses R loop-impeded replication forks through a MUS81-mediated mechanism and protects replication forks from excessive MUS81 cleavage, revealing a MUS81-triggered and ATR-mediated feedback loop safeguarding the genome against R loops.

AB - R loops cause genomic instability, but how cells respond to R loop-associated genomic stress is poorly understood. Matos et al. show that the ATR-Chk1 pathway senses R loop-impeded replication forks through a MUS81-mediated mechanism and protects replication forks from excessive MUS81 cleavage, revealing a MUS81-triggered and ATR-mediated feedback loop safeguarding the genome against R loops.

KW - ATR

KW - Chk1

KW - Fork reversal

KW - Genomic Instability

KW - MUS81

KW - R loop

KW - checkpoint

UR - http://www.scopus.com/inward/record.url?scp=85078771457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85078771457&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2019.10.010

DO - 10.1016/j.molcel.2019.10.010

M3 - Article

C2 - 31708417

AN - SCOPUS:85078771457

SN - 1097-2765

VL - 77

SP - 514-527.e4

JO - Molecular Cell

JF - Molecular Cell

IS - 3

ER -

ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this