Auditory oddball hypoactivation in schizophrenia

Soichiro Nakahara; Alie G. Male; Jessica A. Turner; Vince D. Calhoun; Kelvin O. Lim; Bryon A. Mueller; Juan R. Bustillo; Daniel S. O'Leary; James Voyvodic; Aysenil Belger; Adrian Preda; Daniel H. Mathalon; Judith M. Ford; Guia Guffanti; Fabio Macciardi; Steven G. Potkin; Theo G.M. Van Erp

doi:10.1016/j.pscychresns.2023.111710

Auditory oddball hypoactivation in schizophrenia

Soichiro Nakahara, Alie G. Male, Jessica A. Turner, Vince D. Calhoun, Kelvin O. Lim, Bryon A. Mueller, Juan R. Bustillo, Daniel S. O'Leary, James Voyvodic, Aysenil Belger, Adrian Preda, Daniel H. Mathalon, Judith M. Ford, Guia Guffanti, Fabio Macciardi, Steven G. Potkin, Theo G.M. Van Erp

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Individuals with schizophrenia (SZ) show aberrant activations, assessed via functional magnetic resonance imaging (fMRI), during auditory oddball tasks. However, associations with cognitive performance and genetic contributions remain unknown. This study compares individuals with SZ to healthy volunteers (HVs) using two cross-sectional data sets from multi-center brain imaging studies. It examines brain activation to auditory oddball targets, and their associations with cognitive domain performance, schizophrenia polygenic risk scores (PRS), and genetic variation (loci). Both sample 1 (137 SZ vs. 147 HV) and sample 2 (91 SZ vs. 98 HV), showed hypoactivation in SZ in the left-frontal pole, and right frontal orbital, frontal pole, paracingulate, intracalcarine, precuneus, supramarginal and hippocampal cortices, and right thalamus. In SZ, precuneus activity was positively related to cognitive performance. Schizophrenia PRS showed a negative correlation with brain activity in the right-supramarginal cortex. GWA analyses revealed significant single-nucleotide polymorphisms associated with right-supramarginal gyrus activity. RPL36 also predicted right-supramarginal gyrus activity. In addition to replicating hypoactivation for oddball targets in SZ, this study identifies novel relationships between regional activity, cognitive performance, and genetic loci that warrant replication, emphasizing the need for continued data sharing and collaborative efforts.

Original language	English (US)
Article number	111710
Journal	Psychiatry Research - Neuroimaging
Volume	335
DOIs	https://doi.org/10.1016/j.pscychresns.2023.111710
State	Published - Oct 2023

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Publisher Copyright:
© 2023

Keywords

Cognition
Functional MRI
Genome-wide association analysis
Imaging
Polygenic risk score
Replication

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Nakahara, S., Male, A. G., Turner, J. A., Calhoun, V. D., Lim, K. O., Mueller, B. A., Bustillo, J. R., O'Leary, D. S., Voyvodic, J., Belger, A., Preda, A., Mathalon, D. H., Ford, J. M., Guffanti, G., Macciardi, F., Potkin, S. G., & Van Erp, T. G. M. (2023). Auditory oddball hypoactivation in schizophrenia. Psychiatry Research - Neuroimaging, 335, Article 111710. https://doi.org/10.1016/j.pscychresns.2023.111710

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title = "Auditory oddball hypoactivation in schizophrenia",

abstract = "Individuals with schizophrenia (SZ) show aberrant activations, assessed via functional magnetic resonance imaging (fMRI), during auditory oddball tasks. However, associations with cognitive performance and genetic contributions remain unknown. This study compares individuals with SZ to healthy volunteers (HVs) using two cross-sectional data sets from multi-center brain imaging studies. It examines brain activation to auditory oddball targets, and their associations with cognitive domain performance, schizophrenia polygenic risk scores (PRS), and genetic variation (loci). Both sample 1 (137 SZ vs. 147 HV) and sample 2 (91 SZ vs. 98 HV), showed hypoactivation in SZ in the left-frontal pole, and right frontal orbital, frontal pole, paracingulate, intracalcarine, precuneus, supramarginal and hippocampal cortices, and right thalamus. In SZ, precuneus activity was positively related to cognitive performance. Schizophrenia PRS showed a negative correlation with brain activity in the right-supramarginal cortex. GWA analyses revealed significant single-nucleotide polymorphisms associated with right-supramarginal gyrus activity. RPL36 also predicted right-supramarginal gyrus activity. In addition to replicating hypoactivation for oddball targets in SZ, this study identifies novel relationships between regional activity, cognitive performance, and genetic loci that warrant replication, emphasizing the need for continued data sharing and collaborative efforts.",

keywords = "Cognition, Functional MRI, Genome-wide association analysis, Imaging, Polygenic risk score, Replication",

author = "Soichiro Nakahara and Male, {Alie G.} and Turner, {Jessica A.} and Calhoun, {Vince D.} and Lim, {Kelvin O.} and Mueller, {Bryon A.} and Bustillo, {Juan R.} and O'Leary, {Daniel S.} and James Voyvodic and Aysenil Belger and Adrian Preda and Mathalon, {Daniel H.} and Ford, {Judith M.} and Guia Guffanti and Fabio Macciardi and Potkin, {Steven G.} and {Van Erp}, {Theo G.M.}",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = oct,

doi = "10.1016/j.pscychresns.2023.111710",

language = "English (US)",

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AU - Nakahara, Soichiro

AU - Male, Alie G.

AU - Turner, Jessica A.

AU - Calhoun, Vince D.

AU - Lim, Kelvin O.

AU - Mueller, Bryon A.

AU - Bustillo, Juan R.

AU - O'Leary, Daniel S.

AU - Voyvodic, James

AU - Belger, Aysenil

AU - Preda, Adrian

AU - Mathalon, Daniel H.

AU - Ford, Judith M.

AU - Guffanti, Guia

AU - Macciardi, Fabio

AU - Potkin, Steven G.

AU - Van Erp, Theo G.M.

PY - 2023/10

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N2 - Individuals with schizophrenia (SZ) show aberrant activations, assessed via functional magnetic resonance imaging (fMRI), during auditory oddball tasks. However, associations with cognitive performance and genetic contributions remain unknown. This study compares individuals with SZ to healthy volunteers (HVs) using two cross-sectional data sets from multi-center brain imaging studies. It examines brain activation to auditory oddball targets, and their associations with cognitive domain performance, schizophrenia polygenic risk scores (PRS), and genetic variation (loci). Both sample 1 (137 SZ vs. 147 HV) and sample 2 (91 SZ vs. 98 HV), showed hypoactivation in SZ in the left-frontal pole, and right frontal orbital, frontal pole, paracingulate, intracalcarine, precuneus, supramarginal and hippocampal cortices, and right thalamus. In SZ, precuneus activity was positively related to cognitive performance. Schizophrenia PRS showed a negative correlation with brain activity in the right-supramarginal cortex. GWA analyses revealed significant single-nucleotide polymorphisms associated with right-supramarginal gyrus activity. RPL36 also predicted right-supramarginal gyrus activity. In addition to replicating hypoactivation for oddball targets in SZ, this study identifies novel relationships between regional activity, cognitive performance, and genetic loci that warrant replication, emphasizing the need for continued data sharing and collaborative efforts.

AB - Individuals with schizophrenia (SZ) show aberrant activations, assessed via functional magnetic resonance imaging (fMRI), during auditory oddball tasks. However, associations with cognitive performance and genetic contributions remain unknown. This study compares individuals with SZ to healthy volunteers (HVs) using two cross-sectional data sets from multi-center brain imaging studies. It examines brain activation to auditory oddball targets, and their associations with cognitive domain performance, schizophrenia polygenic risk scores (PRS), and genetic variation (loci). Both sample 1 (137 SZ vs. 147 HV) and sample 2 (91 SZ vs. 98 HV), showed hypoactivation in SZ in the left-frontal pole, and right frontal orbital, frontal pole, paracingulate, intracalcarine, precuneus, supramarginal and hippocampal cortices, and right thalamus. In SZ, precuneus activity was positively related to cognitive performance. Schizophrenia PRS showed a negative correlation with brain activity in the right-supramarginal cortex. GWA analyses revealed significant single-nucleotide polymorphisms associated with right-supramarginal gyrus activity. RPL36 also predicted right-supramarginal gyrus activity. In addition to replicating hypoactivation for oddball targets in SZ, this study identifies novel relationships between regional activity, cognitive performance, and genetic loci that warrant replication, emphasizing the need for continued data sharing and collaborative efforts.

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KW - Functional MRI

KW - Genome-wide association analysis

KW - Imaging

KW - Polygenic risk score

KW - Replication

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DO - 10.1016/j.pscychresns.2023.111710

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AN - SCOPUS:85170434129

SN - 0925-4927

VL - 335

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

M1 - 111710

ER -

Auditory oddball hypoactivation in schizophrenia

Abstract

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