TY - JOUR
T1 - B cell receptor expression level determines the fate of developing B lymphocytes
T2 - Receptor editing versus selection
AU - Kouskoff, Valerie
AU - Lacaud, Georges
AU - Pape, Kathryn
AU - Retter, Marc
AU - Nemazee, David
PY - 2000/6/20
Y1 - 2000/6/20
N2 - During B lymphocyte development, antibody genes are assembled by DNA recombination. Successful cell surface expression of IgM promotes developmental progression. However, when antigen receptors bind autoantigen, development is blocked and ongoing antibody gene recombination occurs, which often alters antibody specificity in a process called receptor editing. We demonstrate here a significant role of developmental block and receptor editing in B cell receptor quality control. During development a functional, non-self-reactive receptor undergoes receptor editing if its expression is below a certain threshold. Doubling the receptor gene dose promotes development in the absence of autoantigen, but allows editing when autoantigen is present. Thus, both underexpressed and harmful B cell receptors can undergo correction by receptor editing.
AB - During B lymphocyte development, antibody genes are assembled by DNA recombination. Successful cell surface expression of IgM promotes developmental progression. However, when antigen receptors bind autoantigen, development is blocked and ongoing antibody gene recombination occurs, which often alters antibody specificity in a process called receptor editing. We demonstrate here a significant role of developmental block and receptor editing in B cell receptor quality control. During development a functional, non-self-reactive receptor undergoes receptor editing if its expression is below a certain threshold. Doubling the receptor gene dose promotes development in the absence of autoantigen, but allows editing when autoantigen is present. Thus, both underexpressed and harmful B cell receptors can undergo correction by receptor editing.
UR - http://www.scopus.com/inward/record.url?scp=0034691152&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034691152&partnerID=8YFLogxK
U2 - 10.1073/pnas.130182597
DO - 10.1073/pnas.130182597
M3 - Article
C2 - 10829082
AN - SCOPUS:0034691152
SN - 0027-8424
VL - 97
SP - 7435
EP - 7439
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 13
ER -