TY - JOUR
T1 - Behavioral disinhibition and the development of substance-use disorders
T2 - Findings from the Minnesota twin family study
AU - Iacono, William G.
AU - Carlson, Scott R.
AU - Taylor, Jeanette
AU - Elkins, Irene J.
AU - McGue, Matt
PY - 1999
Y1 - 1999
N2 - One variant of substance-use disorder is characterized by behavioral disinhibition. In this report, we martial evidence for a model for the development of this variant. We hypothesize that genetic liability for this variant is reflected in a spectrum of risk indicators linked to the inability or unwillingness to inhibit behavioral impulses. Included in this spectrum are personality traits suggesting low constraint, and externalizing psychopathology, including conduct, oppositional defiant, and attention-deficit disorder in children and antisocial personality disorder and behavior in adults. We further hypothesize that these individual differences in behavioral disinhibition are manifestations of underlying central nervous system processes associated with various psychophysiological anomalies, some of which may index genetic risk for substance abuse. Support for the model is derived from the analysis of findings from the Minnesota Twin Family Study, an epidemiological investigation of approximately 2,700 adolescent twins and their parents.
AB - One variant of substance-use disorder is characterized by behavioral disinhibition. In this report, we martial evidence for a model for the development of this variant. We hypothesize that genetic liability for this variant is reflected in a spectrum of risk indicators linked to the inability or unwillingness to inhibit behavioral impulses. Included in this spectrum are personality traits suggesting low constraint, and externalizing psychopathology, including conduct, oppositional defiant, and attention-deficit disorder in children and antisocial personality disorder and behavior in adults. We further hypothesize that these individual differences in behavioral disinhibition are manifestations of underlying central nervous system processes associated with various psychophysiological anomalies, some of which may index genetic risk for substance abuse. Support for the model is derived from the analysis of findings from the Minnesota Twin Family Study, an epidemiological investigation of approximately 2,700 adolescent twins and their parents.
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U2 - 10.1017/S0954579499002369
DO - 10.1017/S0954579499002369
M3 - Article
C2 - 10624730
AN - SCOPUS:0033183651
SN - 0954-5794
VL - 11
SP - 869
EP - 900
JO - Development and psychopathology
JF - Development and psychopathology
IS - 4
ER -