Bilateral Ovarian B-Lineage Lymphoblastic Lymphoma with MLL Gene Rearrangement: A Novel Case in Infancy

Alyssa M. Larish; Michelle Dolan; Tim Casey; Joanna L. Perkins

doi:10.1097/MPH.0000000000000296

Bilateral Ovarian B-Lineage Lymphoblastic Lymphoma with MLL Gene Rearrangement: A Novel Case in Infancy

Alyssa M. Larish, Michelle Dolan, Tim Casey, Joanna L. Perkins

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Mixed-lineage leukemia (MLL) gene rearrangements have rarely been reported in pediatric lymphoma despite their high prevalence in pediatric leukemia. We present a case of an infant with bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement. We also briefly summarize the clinicopathologic significance of MLL gene rearrangements, and review the reported cases of pediatric ovarian lymphoma with and without MLL rearrangement.

Original language	English (US)
Pages (from-to)	e215-e217
Journal	Journal of pediatric hematology/oncology
Volume	37
Issue number	4
DOIs	https://doi.org/10.1097/MPH.0000000000000296
State	Published - Dec 1 2015

Keywords

MLL gene rearrangement
childhood cancer
lymphoblastic lymphoma
ovarian lymphoma

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title = "Bilateral Ovarian B-Lineage Lymphoblastic Lymphoma with MLL Gene Rearrangement: A Novel Case in Infancy",

abstract = "Mixed-lineage leukemia (MLL) gene rearrangements have rarely been reported in pediatric lymphoma despite their high prevalence in pediatric leukemia. We present a case of an infant with bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement. We also briefly summarize the clinicopathologic significance of MLL gene rearrangements, and review the reported cases of pediatric ovarian lymphoma with and without MLL rearrangement.",

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AU - Larish, Alyssa M.

AU - Dolan, Michelle

AU - Casey, Tim

AU - Perkins, Joanna L.

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AB - Mixed-lineage leukemia (MLL) gene rearrangements have rarely been reported in pediatric lymphoma despite their high prevalence in pediatric leukemia. We present a case of an infant with bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement. We also briefly summarize the clinicopathologic significance of MLL gene rearrangements, and review the reported cases of pediatric ovarian lymphoma with and without MLL rearrangement.

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KW - childhood cancer

KW - lymphoblastic lymphoma

KW - ovarian lymphoma

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Bilateral Ovarian B-Lineage Lymphoblastic Lymphoma with MLL Gene Rearrangement: A Novel Case in Infancy

Abstract

Keywords

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