Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (AαC) in human bladder RT4 cells

Medicine & Life Sciences

• 2-amino-9H-pyrido(2,3-b)indole 100%
• 4-biphenylamine 80%
• Carcinogens 46%
• Tobacco 46%
• DNA Adducts 45%
• Amines 44%
• Urinary Bladder 38%
• 2-Naphthylamine 31%
• 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine 28%
• Urinary Bladder Neoplasms 23%
• steroid hormone 7-alpha-hydroxylase 20%
• Meat 13%
• Smoke 11%
• Quinoxalines 8%
• Methoxsalen 8%
• Urothelium 7%
• DNA 6%
• Occupational Exposure 6%
• Liquid Chromatography 6%
• Cytochrome P-450 Enzyme System 5%
• Mass Spectrometry 5%
• DNA Damage 5%
• Epidemiologic Studies 5%
• Protein Isoforms 4%
• Carcinogenesis 4%
• Epithelial Cells 4%
• Cell Line 3%

Chemical Compounds

• 2-Amino-9H-pyrido[2,3-b]indole 86%
• Adduct 34%
• Aromatic Amine 30%
• 2-Naphthylamine 22%
• MeIQx 15%
• PhIP 14%
• Smoke 11%
• Quinoxaline 5%
• Cytochrome P450 5%
• Liquid Chromatography Mass Spectrometry (LCMS) 5%
• Pyridine 3%