Bioactive polybrominated diphenyl ethers from the marine sponge Dysidea sp.

Hui Zhang; Andrew J Skildum; Emily Stromquist; Teresa Rose-Hellekant; Chee Chang Leng

doi:10.1021/np070244y

Bioactive polybrominated diphenyl ethers from the marine sponge Dysidea sp.

Hui Zhang, Andrew J Skildum, Emily Stromquist, Teresa Rose-Hellekant, Chee Chang Leng

Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A new polybrominated diphenyl ether (9), together with eight known compounds, were isolated from the crude organic extract of the marine sponge Dysidea sp. collected from the Federated States of Micronesia. Their structures were elucidated on the basis of various NMR spectroscopic data. These compounds exhibited inhibitory activities against Streptomyces 85E in the hyphae formation inhibition (HFI) assay and displayed antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7. Compound 6 was selected for further evaluation in a cell cycle progression study.

Original language	English (US)
Pages (from-to)	262-264
Number of pages	3
Journal	Journal of Natural Products
Volume	71
Issue number	2
DOIs	https://doi.org/10.1021/np070244y
State	Published - Feb 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1021/np070244y

OpenUrl availability

Full text

Cite this

@article{2d9477e3bb1d4efd81ef4308e56aaca9,

title = "Bioactive polybrominated diphenyl ethers from the marine sponge Dysidea sp.",

abstract = "A new polybrominated diphenyl ether (9), together with eight known compounds, were isolated from the crude organic extract of the marine sponge Dysidea sp. collected from the Federated States of Micronesia. Their structures were elucidated on the basis of various NMR spectroscopic data. These compounds exhibited inhibitory activities against Streptomyces 85E in the hyphae formation inhibition (HFI) assay and displayed antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7. Compound 6 was selected for further evaluation in a cell cycle progression study.",

author = "Hui Zhang and Skildum, {Andrew J} and Emily Stromquist and Teresa Rose-Hellekant and Leng, {Chee Chang}",

year = "2008",

month = feb,

doi = "10.1021/np070244y",

language = "English (US)",

volume = "71",

pages = "262--264",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - Bioactive polybrominated diphenyl ethers from the marine sponge Dysidea sp.

AU - Zhang, Hui

AU - Skildum, Andrew J

AU - Stromquist, Emily

AU - Rose-Hellekant, Teresa

AU - Leng, Chee Chang

PY - 2008/2

Y1 - 2008/2

N2 - A new polybrominated diphenyl ether (9), together with eight known compounds, were isolated from the crude organic extract of the marine sponge Dysidea sp. collected from the Federated States of Micronesia. Their structures were elucidated on the basis of various NMR spectroscopic data. These compounds exhibited inhibitory activities against Streptomyces 85E in the hyphae formation inhibition (HFI) assay and displayed antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7. Compound 6 was selected for further evaluation in a cell cycle progression study.

AB - A new polybrominated diphenyl ether (9), together with eight known compounds, were isolated from the crude organic extract of the marine sponge Dysidea sp. collected from the Federated States of Micronesia. Their structures were elucidated on the basis of various NMR spectroscopic data. These compounds exhibited inhibitory activities against Streptomyces 85E in the hyphae formation inhibition (HFI) assay and displayed antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7. Compound 6 was selected for further evaluation in a cell cycle progression study.

UR - http://www.scopus.com/inward/record.url?scp=40549108585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40549108585&partnerID=8YFLogxK

U2 - 10.1021/np070244y

DO - 10.1021/np070244y

M3 - Article

C2 - 18198840

AN - SCOPUS:40549108585

SN - 0163-3864

VL - 71

SP - 262

EP - 264

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

Bioactive polybrominated diphenyl ethers from the marine sponge Dysidea sp.

Abstract

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this