Biodegradation of carbamazepine using freshwater microalgae Chlamydomonas mexicana and Scenedesmus obliquus and the determination of its metabolic fate

Jiu Qiang Xiong; Mayur B. Kurade; Reda A I Abou-Shanab; Min Kyu Ji; Jaeyoung Choi; Jong Oh Kim; Byong Hun Jeon

doi:10.1016/j.biortech.2016.01.038

Biodegradation of carbamazepine using freshwater microalgae Chlamydomonas mexicana and Scenedesmus obliquus and the determination of its metabolic fate

Jiu Qiang Xiong, Mayur B. Kurade, Reda A I Abou-Shanab, Min Kyu Ji, Jaeyoung Choi, Jong Oh Kim, Byong Hun Jeon

Biotechnology Institute

Research output: Contribution to journal › Article › peer-review

311 Scopus citations

Abstract

This study evaluated the toxicity and cellular stresses of carbamazepine (CBZ) on Chlamydomonas mexicana and Scenedesmus obliquus, and its biodegradation by both microalgal species. The growth of both microalgal species decreased with increase of CBZ concentration. The growth of S. obliquus was significantly inhibited (97%) at 200 mg CBZ L^-1, as compared to the control after 10days; whereas, C. mexicana showed 30% inhibition at the same experimental conditions. Biochemical characteristics including total chlorophyll, carotenoid contents and enzyme activities (SOD and CAT) for both species were affected by CBZ at relatively high concentration. C. mexicana and S. obliquus could achieve a maximum of 35% and 28% biodegradation of CBZ, respectively. Two metabolites (10,11-dihydro-10,11-expoxycarbamazepine and n-hydroxy-CBZ) were identified by UPLC-MS, as a result of CBZ biodegradation by C. mexicana. This study demonstrated that C. mexicana was more tolerant to CBZ and could be used for treatment of CBZ contaminated wastewater.

Original language	English (US)
Pages (from-to)	183-190
Number of pages	8
Journal	Bioresource Technology
Volume	205
DOIs	https://doi.org/10.1016/j.biortech.2016.01.038
State	Published - Apr 1 2016

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the South Korea government (MSIP) (No. NRF-2013R1A2A2A07069183 ).

Publisher Copyright:
© 2016 Elsevier Ltd.

Keywords

Biodegradation
Bioremediation
C. mexicana
Carbamazepine
Emerging contaminants

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Biodegradation of carbamazepine using freshwater microalgae Chlamydomonas mexicana and Scenedesmus obliquus and the determination of its metabolic fate",

abstract = "This study evaluated the toxicity and cellular stresses of carbamazepine (CBZ) on Chlamydomonas mexicana and Scenedesmus obliquus, and its biodegradation by both microalgal species. The growth of both microalgal species decreased with increase of CBZ concentration. The growth of S. obliquus was significantly inhibited (97%) at 200 mg CBZ L-1, as compared to the control after 10days; whereas, C. mexicana showed 30% inhibition at the same experimental conditions. Biochemical characteristics including total chlorophyll, carotenoid contents and enzyme activities (SOD and CAT) for both species were affected by CBZ at relatively high concentration. C. mexicana and S. obliquus could achieve a maximum of 35% and 28% biodegradation of CBZ, respectively. Two metabolites (10,11-dihydro-10,11-expoxycarbamazepine and n-hydroxy-CBZ) were identified by UPLC-MS, as a result of CBZ biodegradation by C. mexicana. This study demonstrated that C. mexicana was more tolerant to CBZ and could be used for treatment of CBZ contaminated wastewater.",

keywords = "Biodegradation, Bioremediation, C. mexicana, Carbamazepine, Emerging contaminants",

author = "Xiong, {Jiu Qiang} and Kurade, {Mayur B.} and Abou-Shanab, {Reda A I} and Ji, {Min Kyu} and Jaeyoung Choi and Kim, {Jong Oh} and Jeon, {Byong Hun}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the South Korea government (MSIP) (No. NRF-2013R1A2A2A07069183 ). Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",

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AU - Xiong, Jiu Qiang

AU - Kurade, Mayur B.

AU - Abou-Shanab, Reda A I

AU - Ji, Min Kyu

AU - Choi, Jaeyoung

AU - Kim, Jong Oh

AU - Jeon, Byong Hun

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the South Korea government (MSIP) (No. NRF-2013R1A2A2A07069183 ). Publisher Copyright: © 2016 Elsevier Ltd.

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AB - This study evaluated the toxicity and cellular stresses of carbamazepine (CBZ) on Chlamydomonas mexicana and Scenedesmus obliquus, and its biodegradation by both microalgal species. The growth of both microalgal species decreased with increase of CBZ concentration. The growth of S. obliquus was significantly inhibited (97%) at 200 mg CBZ L-1, as compared to the control after 10days; whereas, C. mexicana showed 30% inhibition at the same experimental conditions. Biochemical characteristics including total chlorophyll, carotenoid contents and enzyme activities (SOD and CAT) for both species were affected by CBZ at relatively high concentration. C. mexicana and S. obliquus could achieve a maximum of 35% and 28% biodegradation of CBZ, respectively. Two metabolites (10,11-dihydro-10,11-expoxycarbamazepine and n-hydroxy-CBZ) were identified by UPLC-MS, as a result of CBZ biodegradation by C. mexicana. This study demonstrated that C. mexicana was more tolerant to CBZ and could be used for treatment of CBZ contaminated wastewater.

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KW - Carbamazepine

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ER -

Biodegradation of carbamazepine using freshwater microalgae Chlamydomonas mexicana and Scenedesmus obliquus and the determination of its metabolic fate

Abstract

Bibliographical note

Keywords

UN SDGs

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