TY - JOUR
T1 - Biological Behavior of Canine Acanthomatous Ameloblastoma Assessed With Computed Tomography and Histopathology
T2 - A Comparative Study
AU - Goldschmidt, Stephanie
AU - Bell, Cynthia
AU - Waller, Kenneth
AU - Hetzel, Scott
AU - Soukup, Jason W.
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2020/9
Y1 - 2020/9
N2 - Canine acanthomatous ameloblastoma (CAA) appears to have variable biological behavior with some tumors presenting with slow growth and minimal bone loss while others grow rapidly and cause severe cancellous and cortical bone destruction. The primary aim of the study is to elucidate if variations (grades) of CAA can be identified based on both histological and diagnostic imaging indices, and to compare markers of more aggressive behavior between these 2 commonly used diagnostic tools. This study evaluated 45 cases of CAA and confirmed that there is high degree of variability in tumor invasiveness as measured with computed tomography, with predominantly intraosseous tumors being significantly associated with more invasive behavior. However, the analysis also identified that there was very little correlation between computed tomographic and histological appearance of the tumor. CAA tends to have a highly uniform and predictable histological pattern, with tumors that aggressively invade bone (as seen on CT) not showing features of atypia that might be helpful in predicting the biological behavior of the neoplastic cells. Thus, reliance on diagnostic imaging as a measure of biological behavior is recommended for treatment planning as well as possible creation of a variant/grading scheme. Prospective studies are required to evaluate if differing variants of CAA as based on diagnostic imaging should be treated differently, and how this would affect long term clinical outcome.
AB - Canine acanthomatous ameloblastoma (CAA) appears to have variable biological behavior with some tumors presenting with slow growth and minimal bone loss while others grow rapidly and cause severe cancellous and cortical bone destruction. The primary aim of the study is to elucidate if variations (grades) of CAA can be identified based on both histological and diagnostic imaging indices, and to compare markers of more aggressive behavior between these 2 commonly used diagnostic tools. This study evaluated 45 cases of CAA and confirmed that there is high degree of variability in tumor invasiveness as measured with computed tomography, with predominantly intraosseous tumors being significantly associated with more invasive behavior. However, the analysis also identified that there was very little correlation between computed tomographic and histological appearance of the tumor. CAA tends to have a highly uniform and predictable histological pattern, with tumors that aggressively invade bone (as seen on CT) not showing features of atypia that might be helpful in predicting the biological behavior of the neoplastic cells. Thus, reliance on diagnostic imaging as a measure of biological behavior is recommended for treatment planning as well as possible creation of a variant/grading scheme. Prospective studies are required to evaluate if differing variants of CAA as based on diagnostic imaging should be treated differently, and how this would affect long term clinical outcome.
KW - acanthomatous ameloblastoma
KW - acanthomatous epulis
KW - ameloblastoma
KW - odontogenic
KW - odontogenic tumor
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U2 - 10.1177/0898756420969869
DO - 10.1177/0898756420969869
M3 - Article
C2 - 33167755
AN - SCOPUS:85095858528
SN - 0898-7564
VL - 37
SP - 126
EP - 132
JO - Journal of Veterinary Dentistry
JF - Journal of Veterinary Dentistry
IS - 3
ER -