TY - JOUR
T1 - Biology evolves to fight chemistry
AU - Kazlauskas, Romas
PY - 2012/4/20
Y1 - 2012/4/20
N2 - A human enzyme variant, PON1-G3C9, accidentally catalyzes the hydrolysis of organophosphorus chemical weapons. In this issue of Chemistry & Biology, Goldsmith and coworkers describe a new PON1 variant with improved hydrolysis by several hundred fold; enough that it may protect animals from a toxic dose.
AB - A human enzyme variant, PON1-G3C9, accidentally catalyzes the hydrolysis of organophosphorus chemical weapons. In this issue of Chemistry & Biology, Goldsmith and coworkers describe a new PON1 variant with improved hydrolysis by several hundred fold; enough that it may protect animals from a toxic dose.
UR - http://www.scopus.com/inward/record.url?scp=84860204671&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860204671&partnerID=8YFLogxK
U2 - 10.1016/j.chembiol.2012.04.004
DO - 10.1016/j.chembiol.2012.04.004
M3 - Short survey
C2 - 22520746
AN - SCOPUS:84860204671
SN - 1074-5521
VL - 19
SP - 435
EP - 437
JO - Chemistry and Biology
JF - Chemistry and Biology
IS - 4
ER -