Biomarkers and Cognitive Function in Children and Adolescents During Maintenance Therapy for Leukemia

Mary C. Hooke; Michelle A. Mathiason; Alicia S. Kunin-Batson; Audrey Blommer; Jessica Hutter; Pauline A. Mitby; Ida M. Moore; Susan Whitman; Olga Taylor; Michael E. Scheurer; Marilyn J. Hockenberry

doi:10.1188/21.ONF.623-633

Biomarkers and Cognitive Function in Children and Adolescents During Maintenance Therapy for Leukemia

Mary C. Hooke, Michelle A. Mathiason, Alicia S. Kunin-Batson, Audrey Blommer, Jessica Hutter, Pauline A. Mitby, Ida M. Moore, Susan Whitman, Olga Taylor, Michael E. Scheurer, Marilyn J. Hockenberry

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4 Scopus citations

Abstract

OBJECTIVES: To explore the relationship between biomarkers of oxidative stress and inflmmation in cerebrospinal fluid (CSF) and cognitive function in children receiving maintenance therapy for acute lymphocytic leukemia (ALL). SAMPLE & SETTING: 30 participants aged 4-17 years receiving ALL maintenance therapy at two pediatric cancer centers in the United States. METHODS & VARIABLES: F2-isoprostane (F2-ISoP) and interleukin-8 (IL-8) were evaluated in CSF samples, and cognitive function measures were completed during the first and last cycles of ALL maintenance. The Flanker Inhibitory Control and Attention Test (Flanker) and Dimensional Change Card Sort were completed during the last cycle. RESULTS: During maintenance therapy, IL-8 decreased, and parent reports of children's cognitive function improved. Higher IL-8 was associated with better parent reports of children's cognitive function at each timepoint. Higher F2-ISoP levels were associated with lower Flanker scores. IMPLICATIONS FOR NURSING: F2-ISoP may be a useful biomarker in evaluating cognitive dysfunction in children with ALL and merits further investigation.

Original language	English (US)
Pages (from-to)	623-633
Number of pages	11
Journal	Oncology nursing forum
Volume	48
Issue number	6
DOIs	https://doi.org/10.1188/21.ONF.623-633
State	Published - Nov 2021

Bibliographical note

Funding Information:
dean of the College of Nursing, and Susan Whitman, MS, is a scientist III in the College of Medicine, both at the University of Arizona in Tucson; and Olga Taylor, MPH, is a clinical research manager, Michael E. Scheurer, PhD, MPH, is a professor of pediatrics and hematology-oncology, and Marilyn J. Hockenberry, PhD, RN, PPCNP, FAAN, is a professor of pediatrics and the director of Global HOPE Nursing, all at the Baylor College of Medicine in Houston, TX. Hooke can be reached at hook0035@umn.edu, with copy to ONFEditor@ons .org. (Submitted January 2021. Accepted May 19, 2021.) This work was supported, in part, by a grant from the Arthur Olofson Medical Research Fund at the University of Minnesota Foundation and the National Institutes of Health (R01CA1693398).

Publisher Copyright:
© 2021 Oncology Nursing Society. All rights reserved.

Keywords

Acute lymphoblastic leukemia
Biomarkers
Childhood cancer
Cognitive function

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Biomarkers and Cognitive Function in Children and Adolescents During Maintenance Therapy for Leukemia",

abstract = "OBJECTIVES: To explore the relationship between biomarkers of oxidative stress and inflmmation in cerebrospinal fluid (CSF) and cognitive function in children receiving maintenance therapy for acute lymphocytic leukemia (ALL). SAMPLE & SETTING: 30 participants aged 4-17 years receiving ALL maintenance therapy at two pediatric cancer centers in the United States. METHODS & VARIABLES: F2-isoprostane (F2-ISoP) and interleukin-8 (IL-8) were evaluated in CSF samples, and cognitive function measures were completed during the first and last cycles of ALL maintenance. The Flanker Inhibitory Control and Attention Test (Flanker) and Dimensional Change Card Sort were completed during the last cycle. RESULTS: During maintenance therapy, IL-8 decreased, and parent reports of children's cognitive function improved. Higher IL-8 was associated with better parent reports of children's cognitive function at each timepoint. Higher F2-ISoP levels were associated with lower Flanker scores. IMPLICATIONS FOR NURSING: F2-ISoP may be a useful biomarker in evaluating cognitive dysfunction in children with ALL and merits further investigation.",

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note = "Funding Information: dean of the College of Nursing, and Susan Whitman, MS, is a scientist III in the College of Medicine, both at the University of Arizona in Tucson; and Olga Taylor, MPH, is a clinical research manager, Michael E. Scheurer, PhD, MPH, is a professor of pediatrics and hematology-oncology, and Marilyn J. Hockenberry, PhD, RN, PPCNP, FAAN, is a professor of pediatrics and the director of Global HOPE Nursing, all at the Baylor College of Medicine in Houston, TX. Hooke can be reached at hook0035@umn.edu, with copy to ONFEditor@ons .org. (Submitted January 2021. Accepted May 19, 2021.) This work was supported, in part, by a grant from the Arthur Olofson Medical Research Fund at the University of Minnesota Foundation and the National Institutes of Health (R01CA1693398). Publisher Copyright: {\textcopyright} 2021 Oncology Nursing Society. All rights reserved.",

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AU - Hooke, Mary C.

AU - Mathiason, Michelle A.

AU - Kunin-Batson, Alicia S.

AU - Blommer, Audrey

AU - Hutter, Jessica

AU - Mitby, Pauline A.

AU - Moore, Ida M.

AU - Whitman, Susan

AU - Taylor, Olga

AU - Scheurer, Michael E.

AU - Hockenberry, Marilyn J.

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N2 - OBJECTIVES: To explore the relationship between biomarkers of oxidative stress and inflmmation in cerebrospinal fluid (CSF) and cognitive function in children receiving maintenance therapy for acute lymphocytic leukemia (ALL). SAMPLE & SETTING: 30 participants aged 4-17 years receiving ALL maintenance therapy at two pediatric cancer centers in the United States. METHODS & VARIABLES: F2-isoprostane (F2-ISoP) and interleukin-8 (IL-8) were evaluated in CSF samples, and cognitive function measures were completed during the first and last cycles of ALL maintenance. The Flanker Inhibitory Control and Attention Test (Flanker) and Dimensional Change Card Sort were completed during the last cycle. RESULTS: During maintenance therapy, IL-8 decreased, and parent reports of children's cognitive function improved. Higher IL-8 was associated with better parent reports of children's cognitive function at each timepoint. Higher F2-ISoP levels were associated with lower Flanker scores. IMPLICATIONS FOR NURSING: F2-ISoP may be a useful biomarker in evaluating cognitive dysfunction in children with ALL and merits further investigation.

AB - OBJECTIVES: To explore the relationship between biomarkers of oxidative stress and inflmmation in cerebrospinal fluid (CSF) and cognitive function in children receiving maintenance therapy for acute lymphocytic leukemia (ALL). SAMPLE & SETTING: 30 participants aged 4-17 years receiving ALL maintenance therapy at two pediatric cancer centers in the United States. METHODS & VARIABLES: F2-isoprostane (F2-ISoP) and interleukin-8 (IL-8) were evaluated in CSF samples, and cognitive function measures were completed during the first and last cycles of ALL maintenance. The Flanker Inhibitory Control and Attention Test (Flanker) and Dimensional Change Card Sort were completed during the last cycle. RESULTS: During maintenance therapy, IL-8 decreased, and parent reports of children's cognitive function improved. Higher IL-8 was associated with better parent reports of children's cognitive function at each timepoint. Higher F2-ISoP levels were associated with lower Flanker scores. IMPLICATIONS FOR NURSING: F2-ISoP may be a useful biomarker in evaluating cognitive dysfunction in children with ALL and merits further investigation.

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KW - Childhood cancer

KW - Cognitive function

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Biomarkers and Cognitive Function in Children and Adolescents During Maintenance Therapy for Leukemia

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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