Abstract
In this review, we will explore the use of biomarkers in chronic pain, using the examples of two prototypical facial pain conditions: trigeminal neuralgia and temporomandibular disorder. We will discuss the main categories of biomarkers and identify various genetic/genomic, molecular, neuroradiological, and psychophysical biomarkers in both facial pain conditions, using them to compare and contrast features of neuropathic, nonneuropathic, and mixed pain. By using two distinct model facial pain conditions to explore pain biomarkers, we aim to familiarize readers with different types of biomarkers currently being studied in chronic pain and explore how these biomarkers may be used to develop new precision medicine approaches to pain diagnosis, prognosis, and management.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-18 |
| Number of pages | 18 |
| Journal | Canadian Journal of Pain |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2020 |
Bibliographical note
Funding Information:This work was not supported by any grants. Dr. Doshi is supported by a research grant from the Foundation for Anesthesia Education and Research. Dr. Campbell consults for PainCare and Adynxx, Inc. Dr. Raja has received research grants from Medtronic Inc. and has served as an advisory board member for Aptinyx and Lexicon Pharma.
Funding Information:
This work was not supported by any grants. Dr. Doshi is supported by a research grant from the Foundation for Anesthesia Education and Research. Dr. Nixdorf has no conflicts of interest to declare. Dr. Campbell consults for PainCare and Adynxx, Inc. Dr. Raja has received research grants from Medtronic Inc., and has served as an advisory board member for Aptinyx and Lexicon Pharma.
Publisher Copyright:
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
Keywords
- biomarkers
- chronic pain
- facial pain
- precision medicine
- temporomandibular disorder
- trigeminal neuralgia