Abstract
Indeterminate dendritic cell tumor (IDCT) is an exceedingly rare neoplasm that can be associated with hematopoietic malignancies. We report a case of multifocal cutaneous blastic indeterminate dendritic cell tumor (BIDCT) in a 75-year-old man with chronic myelomonocytic leukemia showing blastic histiocytoid morphology, positivity for CD1a and S100, and no expression of langerin. We present a literature review on the 11 reported cases of IDCTs/BIDCTs associated with chronic myelomonocytic leukemia (CMML), including this case. The clinicopathological characteristics have been summarized. The IDCT and CMML cells are clonally related in 4 tested cases. Patients with IDCT/BIDCT associated with CMML seem to have worse clinical outcomes compared with patients with IDCT not associated with CMML.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 691-695 |
| Number of pages | 5 |
| Journal | American Journal of Dermatopathology |
| Volume | 44 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2022 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2022 Lippincott Williams and Wilkins. All rights reserved.
Keywords
- chronic myelomonocytic leukemia
- histiocytic/dendritic cell tumor
- indeterminate dendritic cell tumor
- leukemia cutis
PubMed: MeSH publication types
- Case Reports
- Journal Article
- Review
