TY - JOUR
T1 - Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies
AU - The Fatty Acids and Outcomes Research Consortium (FORCE)
AU - Harris, William S.
AU - Tintle, Nathan L.
AU - Imamura, Fumiaki
AU - Qian, Frank
AU - Korat, Andres V.Ardisson
AU - Marklund, Matti
AU - Djoussé, Luc
AU - Bassett, Julie K.
AU - Carmichael, Pierre Hugues
AU - Chen, Yun Yu
AU - Hirakawa, Yoichiro
AU - Küpers, Leanne K.
AU - Laguzzi, Federica
AU - Lankinen, Maria
AU - Murphy, Rachel A.
AU - Samieri, Cécilia
AU - Senn, Mackenzie K.
AU - Shi, Peilin
AU - Virtanen, Jyrki K.
AU - Brouwer, Ingeborg A.
AU - Chien, Kuo Liong
AU - Eiriksdottir, Gudny
AU - Forouhi, Nita G.
AU - Geleijnse, Johanna M.
AU - Giles, Graham G.
AU - Gudnason, Vilmundur
AU - Helmer, Catherine
AU - Hodge, Allison
AU - Jackson, Rebecca
AU - Khaw, Kay Tee
AU - Laakso, Markku
AU - Lai, Heidi
AU - Laurin, Danielle
AU - Leander, Karin
AU - Lindsay, Joan
AU - Micha, Renata
AU - Mursu, Jaako
AU - Ninomiya, Toshiharu
AU - Post, Wendy
AU - Psaty, Bruce M.
AU - Risérus, Ulf
AU - Robinson, Jennifer G.
AU - Shadyab, Aladdin H.
AU - Snetselaar, Linda
AU - Sala-Vila, Aleix
AU - Sun, Yangbo
AU - Steffen, Lyn M.
AU - Tsai, Michael Y.
AU - Wareham, Nicholas J.
AU - Wood, Alexis C.
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12/1
Y1 - 2021/12/1
N2 - The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15–18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20–22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.
AB - The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15–18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20–22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.
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UR - http://www.scopus.com/inward/citedby.url?scp=85105757201&partnerID=8YFLogxK
U2 - 10.1038/s41467-021-22370-2
DO - 10.1038/s41467-021-22370-2
M3 - Article
C2 - 33888689
AN - SCOPUS:85105757201
SN - 2041-1723
VL - 12
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 2329
ER -
