BNT162b2 mRNA Vaccination Against Coronavirus Disease 2019 is Associated With a Decreased Likelihood of Multisystem Inflammatory Syndrome in Children Aged 5-18 Years - United States, July 2021 - April 2022

Laura D. Zambrano; Margaret M. Newhams; Samantha M. Olson; Natasha B. Halasa; Ashley M. Price; Amber O. Orzel; Cameron C. Young; Julie A. Boom; Leila C. Sahni; Aline B. Maddux; Katherine E. Bline; Satoshi Kamidani; Keiko M. Tarquinio; Kathleen Chiotos; Jennifer E. Schuster; Melissa L. Cullimore; Sabrina M. Heidemann; Charlotte V. Hobbs; Ryan A. Nofziger; Pia S. Pannaraj; Melissa A. Cameron; Tracie C. Walker; Stephanie P. Schwartz; Kelly N. Michelson; Bria M. Coates; Heidi R. Flori; Elizabeth H. Mack; Laura Smallcomb; Shira J. Gertz; Samina S. Bhumbra; Tamara T. Bradford; Emily R. Levy; Michele Kong; Katherine Irby; Natalie Z. Cvijanovich; Matt S. Zinter; Cindy Bowens; Hillary Crandall; Janet R. Hume; Manish M. Patel; Angela P. Campbell; Adrienne G. Randolph

doi:10.1093/cid/ciac637

BNT162b2 mRNA Vaccination Against Coronavirus Disease 2019 is Associated With a Decreased Likelihood of Multisystem Inflammatory Syndrome in Children Aged 5-18 Years - United States, July 2021 - April 2022

Laura D. Zambrano, Margaret M. Newhams, Samantha M. Olson, Natasha B. Halasa, Ashley M. Price, Amber O. Orzel, Cameron C. Young, Julie A. Boom, Leila C. Sahni, Aline B. Maddux, Katherine E. Bline, Satoshi Kamidani, Keiko M. Tarquinio, Kathleen Chiotos, Jennifer E. Schuster, Melissa L. Cullimore, Sabrina M. Heidemann, Charlotte V. Hobbs, Ryan A. Nofziger, Pia S. PannarajMelissa A. Cameron, Tracie C. Walker, Stephanie P. Schwartz, Kelly N. Michelson, Bria M. Coates, Heidi R. Flori, Elizabeth H. Mack, Laura Smallcomb, Shira J. Gertz, Samina S. Bhumbra, Tamara T. Bradford, Emily R. Levy, Michele Kong, Katherine Irby, Natalie Z. Cvijanovich, Matt S. Zinter, Cindy Bowens, Hillary Crandall, Janet R. Hume, Manish M. Patel, Angela P. Campbell, Adrienne G. Randolph

Pediatrics - Pediatric Critical Care

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Background: Multisystem inflammatory syndrome in children (MIS-C), linked to antecedent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with considerable morbidity. Prevention of SARS-CoV-2 infection or coronavirus disease 2019 (COVID-19) by vaccination might also decrease MIS-C likelihood. Methods: In a multicenter, case-control, public health investigation of children ages 5-18 years hospitalized from 1 July 2021 to 7 April 2022, we compared the odds of being fully vaccinated (2 doses of BNT162b2 vaccine ≥28 days before hospital admission) between MIS-C case-patients and hospital-based controls who tested negative for SARS-CoV-2. These associations were examined by age group, timing of vaccination, and periods of Delta and Omicron variant predominance using multivariable logistic regression. Results: We compared 304 MIS-C case-patients (280 [92%] unvaccinated) with 502 controls (346 [69%] unvaccinated). MIS-C was associated with decreased likelihood of vaccination (adjusted OR [aOR]:. 16; 95% CI:. 10-.26), including among children ages 5-11 years (aOR:. 22; 95% CI:. 10-.52), ages 12-18 years (aOR:. 10; 95% CI:. 05-.19), and during the Delta (aOR:. 06; 95% CI:. 02-.15) and Omicron (aOR:. 22; 95% CI:. 11-.42) variant-predominant periods. This association persisted beyond 120 days after the second dose (aOR:. 08; 95% CI:. 03-.22) in 12-18-year-olds. Among all MIS-C case-patients, 187 (62%) required intensive care unit admission and 280 (92%) vaccine-eligible case-patients were unvaccinated. Conclusions: Vaccination with 2 doses of BNT162b2 is associated with reduced likelihood of MIS-C in children ages 5-18 years. Most vaccine-eligible hospitalized patients with MIS-C were unvaccinated.

Original language	English (US)
Pages (from-to)	E90-E100
Journal	Clinical Infectious Diseases
Volume	76
Issue number	3
DOIs	https://doi.org/10.1093/cid/ciac637
State	Published - Feb 1 2023

Bibliographical note

Publisher Copyright:
© 2022 Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Keywords

COVID-19
MIS-C
Pfizer (BioNTech)
children
vaccine effectiveness

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Zambrano, L. D., Newhams, M. M., Olson, S. M., Halasa, N. B., Price, A. M., Orzel, A. O., Young, C. C., Boom, J. A., Sahni, L. C., Maddux, A. B., Bline, K. E., Kamidani, S., Tarquinio, K. M., Chiotos, K., Schuster, J. E., Cullimore, M. L., Heidemann, S. M., Hobbs, C. V., Nofziger, R. A., ... Randolph, A. G. (2023). BNT162b2 mRNA Vaccination Against Coronavirus Disease 2019 is Associated With a Decreased Likelihood of Multisystem Inflammatory Syndrome in Children Aged 5-18 Years - United States, July 2021 - April 2022. Clinical Infectious Diseases, 76(3), E90-E100. https://doi.org/10.1093/cid/ciac637

BNT162b2 mRNA Vaccination Against Coronavirus Disease 2019 is Associated With a Decreased Likelihood of Multisystem Inflammatory Syndrome in Children Aged 5-18 Years - United States, July 2021 - April 2022. / Zambrano, Laura D.; Newhams, Margaret M.; Olson, Samantha M. et al.
In: Clinical Infectious Diseases, Vol. 76, No. 3, 01.02.2023, p. E90-E100.

Research output: Contribution to journal › Article › peer-review

Zambrano, LD, Newhams, MM, Olson, SM, Halasa, NB, Price, AM, Orzel, AO, Young, CC, Boom, JA, Sahni, LC, Maddux, AB, Bline, KE, Kamidani, S, Tarquinio, KM, Chiotos, K, Schuster, JE, Cullimore, ML, Heidemann, SM, Hobbs, CV, Nofziger, RA, Pannaraj, PS, Cameron, MA, Walker, TC, Schwartz, SP, Michelson, KN, Coates, BM, Flori, HR, Mack, EH, Smallcomb, L, Gertz, SJ, Bhumbra, SS, Bradford, TT, Levy, ER, Kong, M, Irby, K, Cvijanovich, NZ, Zinter, MS, Bowens, C, Crandall, H, Hume, JR, Patel, MM, Campbell, AP & Randolph, AG 2023, 'BNT162b2 mRNA Vaccination Against Coronavirus Disease 2019 is Associated With a Decreased Likelihood of Multisystem Inflammatory Syndrome in Children Aged 5-18 Years - United States, July 2021 - April 2022', Clinical Infectious Diseases, vol. 76, no. 3, pp. E90-E100. https://doi.org/10.1093/cid/ciac637

@article{60bc33e989bc41deb1743a8f0158ef57,

title = "BNT162b2 mRNA Vaccination Against Coronavirus Disease 2019 is Associated With a Decreased Likelihood of Multisystem Inflammatory Syndrome in Children Aged 5-18 Years - United States, July 2021 - April 2022",

abstract = "Background: Multisystem inflammatory syndrome in children (MIS-C), linked to antecedent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with considerable morbidity. Prevention of SARS-CoV-2 infection or coronavirus disease 2019 (COVID-19) by vaccination might also decrease MIS-C likelihood. Methods: In a multicenter, case-control, public health investigation of children ages 5-18 years hospitalized from 1 July 2021 to 7 April 2022, we compared the odds of being fully vaccinated (2 doses of BNT162b2 vaccine ≥28 days before hospital admission) between MIS-C case-patients and hospital-based controls who tested negative for SARS-CoV-2. These associations were examined by age group, timing of vaccination, and periods of Delta and Omicron variant predominance using multivariable logistic regression. Results: We compared 304 MIS-C case-patients (280 [92%] unvaccinated) with 502 controls (346 [69%] unvaccinated). MIS-C was associated with decreased likelihood of vaccination (adjusted OR [aOR]:. 16; 95% CI:. 10-.26), including among children ages 5-11 years (aOR:. 22; 95% CI:. 10-.52), ages 12-18 years (aOR:. 10; 95% CI:. 05-.19), and during the Delta (aOR:. 06; 95% CI:. 02-.15) and Omicron (aOR:. 22; 95% CI:. 11-.42) variant-predominant periods. This association persisted beyond 120 days after the second dose (aOR:. 08; 95% CI:. 03-.22) in 12-18-year-olds. Among all MIS-C case-patients, 187 (62%) required intensive care unit admission and 280 (92%) vaccine-eligible case-patients were unvaccinated. Conclusions: Vaccination with 2 doses of BNT162b2 is associated with reduced likelihood of MIS-C in children ages 5-18 years. Most vaccine-eligible hospitalized patients with MIS-C were unvaccinated.",

keywords = "COVID-19, MIS-C, Pfizer (BioNTech), children, vaccine effectiveness",

author = "Zambrano, {Laura D.} and Newhams, {Margaret M.} and Olson, {Samantha M.} and Halasa, {Natasha B.} and Price, {Ashley M.} and Orzel, {Amber O.} and Young, {Cameron C.} and Boom, {Julie A.} and Sahni, {Leila C.} and Maddux, {Aline B.} and Bline, {Katherine E.} and Satoshi Kamidani and Tarquinio, {Keiko M.} and Kathleen Chiotos and Schuster, {Jennifer E.} and Cullimore, {Melissa L.} and Heidemann, {Sabrina M.} and Hobbs, {Charlotte V.} and Nofziger, {Ryan A.} and Pannaraj, {Pia S.} and Cameron, {Melissa A.} and Walker, {Tracie C.} and Schwartz, {Stephanie P.} and Michelson, {Kelly N.} and Coates, {Bria M.} and Flori, {Heidi R.} and Mack, {Elizabeth H.} and Laura Smallcomb and Gertz, {Shira J.} and Bhumbra, {Samina S.} and Bradford, {Tamara T.} and Levy, {Emily R.} and Michele Kong and Katherine Irby and Cvijanovich, {Natalie Z.} and Zinter, {Matt S.} and Cindy Bowens and Hillary Crandall and Hume, {Janet R.} and Patel, {Manish M.} and Campbell, {Angela P.} and Randolph, {Adrienne G.}",

note = "Publisher Copyright: {\textcopyright} 2022 Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2023",

month = feb,

day = "1",

doi = "10.1093/cid/ciac637",

language = "English (US)",

volume = "76",

pages = "E90--E100",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

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TY - JOUR

T1 - BNT162b2 mRNA Vaccination Against Coronavirus Disease 2019 is Associated With a Decreased Likelihood of Multisystem Inflammatory Syndrome in Children Aged 5-18 Years - United States, July 2021 - April 2022

AU - Zambrano, Laura D.

AU - Newhams, Margaret M.

AU - Olson, Samantha M.

AU - Halasa, Natasha B.

AU - Price, Ashley M.

AU - Orzel, Amber O.

AU - Young, Cameron C.

AU - Boom, Julie A.

AU - Sahni, Leila C.

AU - Maddux, Aline B.

AU - Bline, Katherine E.

AU - Kamidani, Satoshi

AU - Tarquinio, Keiko M.

AU - Chiotos, Kathleen

AU - Schuster, Jennifer E.

AU - Cullimore, Melissa L.

AU - Heidemann, Sabrina M.

AU - Hobbs, Charlotte V.

AU - Nofziger, Ryan A.

AU - Pannaraj, Pia S.

AU - Cameron, Melissa A.

AU - Walker, Tracie C.

AU - Schwartz, Stephanie P.

AU - Michelson, Kelly N.

AU - Coates, Bria M.

AU - Flori, Heidi R.

AU - Mack, Elizabeth H.

AU - Smallcomb, Laura

AU - Gertz, Shira J.

AU - Bhumbra, Samina S.

AU - Bradford, Tamara T.

AU - Levy, Emily R.

AU - Kong, Michele

AU - Irby, Katherine

AU - Cvijanovich, Natalie Z.

AU - Zinter, Matt S.

AU - Bowens, Cindy

AU - Crandall, Hillary

AU - Hume, Janet R.

AU - Patel, Manish M.

AU - Campbell, Angela P.

AU - Randolph, Adrienne G.

PY - 2023/2/1

Y1 - 2023/2/1

N2 - Background: Multisystem inflammatory syndrome in children (MIS-C), linked to antecedent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with considerable morbidity. Prevention of SARS-CoV-2 infection or coronavirus disease 2019 (COVID-19) by vaccination might also decrease MIS-C likelihood. Methods: In a multicenter, case-control, public health investigation of children ages 5-18 years hospitalized from 1 July 2021 to 7 April 2022, we compared the odds of being fully vaccinated (2 doses of BNT162b2 vaccine ≥28 days before hospital admission) between MIS-C case-patients and hospital-based controls who tested negative for SARS-CoV-2. These associations were examined by age group, timing of vaccination, and periods of Delta and Omicron variant predominance using multivariable logistic regression. Results: We compared 304 MIS-C case-patients (280 [92%] unvaccinated) with 502 controls (346 [69%] unvaccinated). MIS-C was associated with decreased likelihood of vaccination (adjusted OR [aOR]:. 16; 95% CI:. 10-.26), including among children ages 5-11 years (aOR:. 22; 95% CI:. 10-.52), ages 12-18 years (aOR:. 10; 95% CI:. 05-.19), and during the Delta (aOR:. 06; 95% CI:. 02-.15) and Omicron (aOR:. 22; 95% CI:. 11-.42) variant-predominant periods. This association persisted beyond 120 days after the second dose (aOR:. 08; 95% CI:. 03-.22) in 12-18-year-olds. Among all MIS-C case-patients, 187 (62%) required intensive care unit admission and 280 (92%) vaccine-eligible case-patients were unvaccinated. Conclusions: Vaccination with 2 doses of BNT162b2 is associated with reduced likelihood of MIS-C in children ages 5-18 years. Most vaccine-eligible hospitalized patients with MIS-C were unvaccinated.

AB - Background: Multisystem inflammatory syndrome in children (MIS-C), linked to antecedent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with considerable morbidity. Prevention of SARS-CoV-2 infection or coronavirus disease 2019 (COVID-19) by vaccination might also decrease MIS-C likelihood. Methods: In a multicenter, case-control, public health investigation of children ages 5-18 years hospitalized from 1 July 2021 to 7 April 2022, we compared the odds of being fully vaccinated (2 doses of BNT162b2 vaccine ≥28 days before hospital admission) between MIS-C case-patients and hospital-based controls who tested negative for SARS-CoV-2. These associations were examined by age group, timing of vaccination, and periods of Delta and Omicron variant predominance using multivariable logistic regression. Results: We compared 304 MIS-C case-patients (280 [92%] unvaccinated) with 502 controls (346 [69%] unvaccinated). MIS-C was associated with decreased likelihood of vaccination (adjusted OR [aOR]:. 16; 95% CI:. 10-.26), including among children ages 5-11 years (aOR:. 22; 95% CI:. 10-.52), ages 12-18 years (aOR:. 10; 95% CI:. 05-.19), and during the Delta (aOR:. 06; 95% CI:. 02-.15) and Omicron (aOR:. 22; 95% CI:. 11-.42) variant-predominant periods. This association persisted beyond 120 days after the second dose (aOR:. 08; 95% CI:. 03-.22) in 12-18-year-olds. Among all MIS-C case-patients, 187 (62%) required intensive care unit admission and 280 (92%) vaccine-eligible case-patients were unvaccinated. Conclusions: Vaccination with 2 doses of BNT162b2 is associated with reduced likelihood of MIS-C in children ages 5-18 years. Most vaccine-eligible hospitalized patients with MIS-C were unvaccinated.

KW - COVID-19

KW - MIS-C

KW - Pfizer (BioNTech)

KW - children

KW - vaccine effectiveness

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DO - 10.1093/cid/ciac637

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C2 - 35924406

AN - SCOPUS:85147783149

SN - 1058-4838

VL - 76

SP - E90-E100

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 3

ER -

BNT162b2 mRNA Vaccination Against Coronavirus Disease 2019 is Associated With a Decreased Likelihood of Multisystem Inflammatory Syndrome in Children Aged 5-18 Years - United States, July 2021 - April 2022

Abstract

Bibliographical note

Keywords

UN SDGs

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