Bone-Inspired Mineralization with Highly Aligned Cellulose Nanofibers as Template

Zheng Cheng; Zhou Ye; Avi Natan; Yi Ma; Hongyan Li; Yong Chen; Liqiang Wan; Conrado Aparicio; Hongli Zhu

doi:10.1021/acsami.9b15234

Bone-Inspired Mineralization with Highly Aligned Cellulose Nanofibers as Template

Zheng Cheng, Zhou Ye, Avi Natan, Yi Ma, Hongyan Li, Yong Chen, Liqiang Wan, Conrado Aparicio, Hongli Zhu

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Bioinspired by the aligned structure and building blocks of bone, this work mineralized the aligned bacterial cellulose (BC) through in situ mineralization using CaCl₂ and K₂HPO₄ solutions. The cellulose nanofibers were aligned by a scalable stretching process. The aligned and mineralized bacterial cellulose (AMBC) homogeneously incorporated hydroxyapatite (HAP) with a high mineral content and exhibited excellent mechanical strength. The ordered 3D structure allowed the AMBC composite to achieve a high elastic modulus and hardness and the development of a nanostructure inspired by natural bone. The AMBC composite exhibited an elastic modulus of 10.91 ± 3.26 GPa and hardness of 0.37 ± 0.18 GPa. Compared with the nonaligned mineralized bacterial cellulose (NMBC) composite with mineralized crystals of HAP randomly distributed into the BC scaffolds, the AMBC composite possessed a 210% higher elastic modulus and 95% higher hardness. The obtained AMBC composite had excellent mechanical properties by mimicking the natural structure of bone, which indicated that the organic BC aerogel with aligned nanofibers was a promising template for biomimetic mineralization.

Original language	English (US)
Pages (from-to)	42486-42495
Number of pages	10
Journal	ACS Applied Materials and Interfaces
Volume	11
Issue number	45
DOIs	https://doi.org/10.1021/acsami.9b15234
State	Published - Nov 13 2019

Bibliographical note

Funding Information:
H.Z. acknowledges the financial support from NSF ECCSEPMD: 1933051. We thank the Kostas Research Institute at Northeastern University for the use of their facilities and Dr. David Nedrelow for his technical support during nanoindentation tests.

Funding Information:
H.Z. acknowledges the financial support from NSF ECCSEPMD: 1933051. We thank the Kostas Research Institute at Northeastern University for the use of their facilities and Dr. David Nedrelow for his technical support during nanoindentation tests.

Publisher Copyright:
© 2019 American Chemical Society.

Keywords

alignment
bacterial nanocellulose
biomimetic mineralization
hardness
hydroxyapatite composite

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title = "Bone-Inspired Mineralization with Highly Aligned Cellulose Nanofibers as Template",

abstract = "Bioinspired by the aligned structure and building blocks of bone, this work mineralized the aligned bacterial cellulose (BC) through in situ mineralization using CaCl2 and K2HPO4 solutions. The cellulose nanofibers were aligned by a scalable stretching process. The aligned and mineralized bacterial cellulose (AMBC) homogeneously incorporated hydroxyapatite (HAP) with a high mineral content and exhibited excellent mechanical strength. The ordered 3D structure allowed the AMBC composite to achieve a high elastic modulus and hardness and the development of a nanostructure inspired by natural bone. The AMBC composite exhibited an elastic modulus of 10.91 ± 3.26 GPa and hardness of 0.37 ± 0.18 GPa. Compared with the nonaligned mineralized bacterial cellulose (NMBC) composite with mineralized crystals of HAP randomly distributed into the BC scaffolds, the AMBC composite possessed a 210% higher elastic modulus and 95% higher hardness. The obtained AMBC composite had excellent mechanical properties by mimicking the natural structure of bone, which indicated that the organic BC aerogel with aligned nanofibers was a promising template for biomimetic mineralization.",

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author = "Zheng Cheng and Zhou Ye and Avi Natan and Yi Ma and Hongyan Li and Yong Chen and Liqiang Wan and Conrado Aparicio and Hongli Zhu",

note = "Funding Information: H.Z. acknowledges the financial support from NSF ECCSEPMD: 1933051. We thank the Kostas Research Institute at Northeastern University for the use of their facilities and Dr. David Nedrelow for his technical support during nanoindentation tests. Funding Information: H.Z. acknowledges the financial support from NSF ECCSEPMD: 1933051. We thank the Kostas Research Institute at Northeastern University for the use of their facilities and Dr. David Nedrelow for his technical support during nanoindentation tests. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

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AU - Chen, Yong

AU - Wan, Liqiang

AU - Aparicio, Conrado

AU - Zhu, Hongli

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N2 - Bioinspired by the aligned structure and building blocks of bone, this work mineralized the aligned bacterial cellulose (BC) through in situ mineralization using CaCl2 and K2HPO4 solutions. The cellulose nanofibers were aligned by a scalable stretching process. The aligned and mineralized bacterial cellulose (AMBC) homogeneously incorporated hydroxyapatite (HAP) with a high mineral content and exhibited excellent mechanical strength. The ordered 3D structure allowed the AMBC composite to achieve a high elastic modulus and hardness and the development of a nanostructure inspired by natural bone. The AMBC composite exhibited an elastic modulus of 10.91 ± 3.26 GPa and hardness of 0.37 ± 0.18 GPa. Compared with the nonaligned mineralized bacterial cellulose (NMBC) composite with mineralized crystals of HAP randomly distributed into the BC scaffolds, the AMBC composite possessed a 210% higher elastic modulus and 95% higher hardness. The obtained AMBC composite had excellent mechanical properties by mimicking the natural structure of bone, which indicated that the organic BC aerogel with aligned nanofibers was a promising template for biomimetic mineralization.

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Bone-Inspired Mineralization with Highly Aligned Cellulose Nanofibers as Template

Abstract

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Keywords

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