TY - JOUR
T1 - Brain network effects by continuous theta burst stimulation in mal de débarquement syndrome
T2 - Simultaneous EEG and fMRI study
AU - Chen, Yafen
AU - Cha, Yoon Hee
AU - Gleghorn, Diamond
AU - Doudican, Benjamin C.
AU - Shou, Guofa
AU - Ding, Lei
AU - Yuan, Han
N1 - Publisher Copyright:
© 2021 Institute of Physics Publishing. All rights reserved.
PY - 2021/12
Y1 - 2021/12
N2 - Objective. Heterogeneous clinical responses to treatment with non-invasive brain stimulation are commonly observed, making it necessary to determine personally optimized stimulation parameters. We investigated neuroimaging markers of effective brain targets of treatment with continuous theta burst stimulation (cTBS) in mal de débarquement syndrome (MdDS), a balance disorder of persistent oscillating vertigo previously shown to exhibit abnormal intrinsic functional connectivity. Approach. Twenty-four right-handed, cTBS-naive individuals with MdDS received single administrations of cTBS over one of three stimulation targets in randomized order. The optimal target was determined based on the assessment of acute changes after the administration of cTBS over each target. Repetitive cTBS sessions were delivered on three consecutive days with the optimal target chosen by the participant. Electroencephalography (EEG) was recorded at single-Administration test sessions of cTBS. Simultaneous EEG and functional MRI data were acquired at baseline and after completion of 10 12 sessions. Network connectivity changes after single and repetitive stimulations of cTBS were analyzed. Main results. Using electrophysiological source imaging and a data-driven method, we identified network-level connectivity changes in EEG that correlated with symptom responses after completion of multiple sessions of cTBS. We further determined that connectivity changes demonstrated by EEG during test sessions of single administrations of cTBS were signatures that could predict optimal targets. Significance. Our findings demonstrate the effect of cTBS on resting state brain networks and suggest an imaging-based, closed-loop stimulation paradigm that can identify optimal targets during short-Term test sessions of stimulation.
AB - Objective. Heterogeneous clinical responses to treatment with non-invasive brain stimulation are commonly observed, making it necessary to determine personally optimized stimulation parameters. We investigated neuroimaging markers of effective brain targets of treatment with continuous theta burst stimulation (cTBS) in mal de débarquement syndrome (MdDS), a balance disorder of persistent oscillating vertigo previously shown to exhibit abnormal intrinsic functional connectivity. Approach. Twenty-four right-handed, cTBS-naive individuals with MdDS received single administrations of cTBS over one of three stimulation targets in randomized order. The optimal target was determined based on the assessment of acute changes after the administration of cTBS over each target. Repetitive cTBS sessions were delivered on three consecutive days with the optimal target chosen by the participant. Electroencephalography (EEG) was recorded at single-Administration test sessions of cTBS. Simultaneous EEG and functional MRI data were acquired at baseline and after completion of 10 12 sessions. Network connectivity changes after single and repetitive stimulations of cTBS were analyzed. Main results. Using electrophysiological source imaging and a data-driven method, we identified network-level connectivity changes in EEG that correlated with symptom responses after completion of multiple sessions of cTBS. We further determined that connectivity changes demonstrated by EEG during test sessions of single administrations of cTBS were signatures that could predict optimal targets. Significance. Our findings demonstrate the effect of cTBS on resting state brain networks and suggest an imaging-based, closed-loop stimulation paradigm that can identify optimal targets during short-Term test sessions of stimulation.
KW - Continuous theta burst stimulation
KW - EEG
KW - Functional connectivity
KW - Mal de débarquement syndrome
KW - Resting state networks
KW - fMRI
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U2 - 10.1088/1741-2552/ac314b
DO - 10.1088/1741-2552/ac314b
M3 - Article
C2 - 34670201
AN - SCOPUS:85120831250
SN - 1741-2560
VL - 18
JO - Journal of neural engineering
JF - Journal of neural engineering
IS - 6
M1 - 066025
ER -