Abstract
Bronchorrhea, defined as production of voluminous watery sputum greater than 100 mL/d, is a debilitating symptom mostly found in end-stage lung cancer, specifically in invasive mucinous adenocarcinomas. Very rarely, it can primarily contribute to hypoxic respiratory failure and found in a critical care setting. We report a case of a 51-year-old woman diagnosed with having mucinous adenocarcinoma of the lung who presented to the intensive care unit with rapidly worsening respiratory failure and found to have massive bronchorrhea with daily sputum volume exceeding 1000 mL/d at its peak. With the limited quantity and quality of evidence available for the treatment of this condition, multiple agents were tried without considerable benefit. We discuss the pathogenesis of this condition and the different treatment options that can be used for palliation of the sputum volume.
Original language | English (US) |
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Article number | 100398 |
Journal | JTO Clinical and Research Reports |
Volume | 3 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2022 |
Externally published | Yes |
Bibliographical note
Funding Information:Informed consent was obtained from the patient's next of kin for this publication.
Publisher Copyright:
© 2022 The Authors
Keywords
- Bronchorrhea
- Case report
- EGFR inhibitors
- Invasive mucinous adenocarcinomas
- Lung cancer
- Respiratory failure
PubMed: MeSH publication types
- Case Reports