Calcergy in murine progressive ankylosis

H. E. Krug; M. L. Mahowald

doi:10.1007/BF01993298

Calcergy in murine progressive ankylosis

H. E. Krug, M. L. Mahowald

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Abstract

Murine progressive ankylosis (MPA) is characterized by periarticular ossification and joint ankylosis. We studied calcergy and calciphylaxis in MPA. Calcergy represents a chemical attraction betwen heavy metal salts and apatite followed by hydroxyapatite deposition around collagen Mice were injected subcutaneously with FeCl₂, PbAcetate, and saline, and sacrificed at intervals between 5 minutes and 14 days. Section of skin and subcutaneous tissues were stained with Von Kossa's stain. No mice developed calcifylaxis. PbAcetate produced calcergy in all mice. MPA mice exhibited calcergy qualitatively and quantitatively the same as normal mice suggesting abnormal calcergy is not responsible for joint ankylosis in MPA.

Original language	English (US)
Pages (from-to)	261-263
Number of pages	3
Journal	Agents and Actions
Volume	34
Issue number	1-2
DOIs	https://doi.org/10.1007/BF01993298
State	Published - Sep 1991
Externally published	Yes

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AB - Murine progressive ankylosis (MPA) is characterized by periarticular ossification and joint ankylosis. We studied calcergy and calciphylaxis in MPA. Calcergy represents a chemical attraction betwen heavy metal salts and apatite followed by hydroxyapatite deposition around collagen Mice were injected subcutaneously with FeCl2, PbAcetate, and saline, and sacrificed at intervals between 5 minutes and 14 days. Section of skin and subcutaneous tissues were stained with Von Kossa's stain. No mice developed calcifylaxis. PbAcetate produced calcergy in all mice. MPA mice exhibited calcergy qualitatively and quantitatively the same as normal mice suggesting abnormal calcergy is not responsible for joint ankylosis in MPA.

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Calcergy in murine progressive ankylosis

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