| Original language | English (US) |
|---|---|
| Pages (from-to) | 203-208 |
| Number of pages | 6 |
| Journal | Blood |
| Volume | 141 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 12 2023 |
Bibliographical note
Funding Information:This work was supported by NIH Grants RO1s HL147562, CA263806, and U18 EB029354 (awarded by NHLBI, NCI, and NIBIB, respectively), and Susan Samueli Integrative Health Institute’s Scholar Award and SCIRE Foundation (K.G.); Diversity Supplement 3R01HL14756203S awarded by NHLBI (S.K.); NIH Grant R01 DK119498 awarded by NIDDK (N.V.D.); American Society of Hematology (ASH) Graduate Hematology Award (H.M.C.); and University of California President’s Fellowship and A.P. Giannini Fellowship and Leadership Award (D.A.A.)
Funding Information:
The authors thank Joni Ricks-Oddie at the Institute for Clinical and Translational Science for statistical support and Yugal Goel at UCI, Mihir Gupta at Johns Hopkins Medical School, and John D. Roberts at Yale School of Medicine for review and constructive criticism. This work was supported by NIH Grants RO1s HL147562, CA263806, and U18 EB029354 (awarded by the National Heart, Lung, and Blood Institute [NHLBI], National Cancer Institute, and National Institute of Biomedical Imaging and Bioengineering, respectively), and Susan Samueli Integrative Health Institute's Scholar Award and SCIRE Foundation (K.G.); Diversity Supplement 3R01HL14756203S awarded by NHLBI (S.K.); NIH Grant R01 DK119498 awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (N.V.D.); American Society of Hematology (ASH) Graduate Hematology Award (H.M.C.); and University of California President's Fellowship and A.P. Giannini Fellowship and Leadership Award (D.A.A.), The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Contribution: H.M.C. performed hyperalgesia testing in CBD-treated mice and necropsies/tissue harvest, analyzed and interpreted the data, and wrote the manuscript; D.A.A. wrote the manuscript and performed data analysis and presentation, tryptase ELISA, necropsies/tissue harvest; R.F. and G.J.V. performed histopathology; N.G. performed substance P, SAP, and MDA assays; J.L. and V.S. performed hyperalgesia testing in Epidiolex-treated mice; S.K. bred, phenotyped, and prepared sickle and control mice; B.A. performed liquid chromatography mass spectrometry assessment; N.V.D. designed, planned, and supervised liquid chromatography mass spectrometry analysis and revised the manuscript; K.G. conceived, designed, planned, and supervised the entire study, interpreted the data, and wrote/edited the manuscript.