Abstract
Cancer survivorship has remarkably improved over the past decades; nevertheless, cancer survivors are burdened with multiple health complications primarily caused by their cancer therapy. Therapy-induced senescence is recognized as a fundamental mechanism contributing to adverse health complications in cancer survivors. In this mini-review, we will discuss the recent literature describing the mechanisms of cancer therapy-induced senescence. We will focus on endothelial cell senescence since it has been shown to be a key player in numerous cardiovascular complications. We will also discuss novel senotherapeutic approaches that have the potential to combat therapy-induced endothelial cell senescence.
Original language | English (US) |
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Article number | 166352 |
Journal | Biochimica et Biophysica Acta - Molecular Basis of Disease |
Volume | 1868 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2022 |
Bibliographical note
Publisher Copyright:© 2022 Elsevier B.V.
Keywords
- Anthracyclines
- Cancer therapy
- Cardio-oncology
- Endothelial cells
- Radiation
- Senescence