TY - JOUR
T1 - Caregiver burden by treatment and clinical characteristics of patients with glioblastoma
AU - Au, Trang H.
AU - Willis, Connor
AU - Reblin, Maija
AU - Peters, Katherine B.
AU - Nghiemphu, Phioanh Leia
AU - Taylor, Jennie W.
AU - Colman, Howard
AU - Cohen, Adam L.
AU - Ormond, D. Ryan
AU - Chakravarti, Arnab
AU - Willmarth, Nicole
AU - Menon, Jyothi
AU - Ma, Junjie
AU - Bauer, Hillevi
AU - Watanabe, Alexandre H.
AU - Ulrich, Cornelia M.
AU - Singh, Prianka
AU - Marshall, Alexander
AU - Korytowsky, Beata
AU - Stenehjem, David
AU - Brixner, Diana
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2022/2
Y1 - 2022/2
N2 - Background: Glioblastoma is an incurable disease with a poor prognosis. For caregivers of people with glioblastoma, the burden of care can be high. Patients often present with different clinical characteristics, which may impact caregiver burden in different ways. This study aimed to evaluate associations between patient clinical characteristics and caregiver burden/quality of life (QoL). Methods: Caregiver–patient dyads were enrolled at 7 academic cancer centers in the United States. Eligible caregiver participants were self-reported as the primary caregiver of an adult living with glioblastoma and completed a caregiver burden survey. Eligible patients were age ≥ 18 years at glioblastoma diagnosis and alive when their respective caregiver entered the study, with the presence of cognitive dysfunction confirmed by the caregiver. Data were analyzed with descriptive statistics and multivariable analyses. Results: The final cohort included 167 dyads. Poor patient performance status resulted in patient difficulty with mental tasks, more caregiving tasks, and increased caregiving time. Language problems were reported in patients with left-sided lesions. Patient confusion was negatively associated with all caregiver domains: emotional health, social health, general health, ability to work, confidence in finances, and overall QoL. Better caregiver QoL was observed in patients with frontal lobe lesions versus non-frontal lobe lesions. Conclusion: This study reinforced that patient performance status is a critical clinical factor that significantly affects caregiver burden, caregiving tasks, and caregiver time. Additionally, patient confusion affects multiple facets of caregiver burden/QoL. These results could be used to support guided intervention for caregiver support, customized to the patient experience.
AB - Background: Glioblastoma is an incurable disease with a poor prognosis. For caregivers of people with glioblastoma, the burden of care can be high. Patients often present with different clinical characteristics, which may impact caregiver burden in different ways. This study aimed to evaluate associations between patient clinical characteristics and caregiver burden/quality of life (QoL). Methods: Caregiver–patient dyads were enrolled at 7 academic cancer centers in the United States. Eligible caregiver participants were self-reported as the primary caregiver of an adult living with glioblastoma and completed a caregiver burden survey. Eligible patients were age ≥ 18 years at glioblastoma diagnosis and alive when their respective caregiver entered the study, with the presence of cognitive dysfunction confirmed by the caregiver. Data were analyzed with descriptive statistics and multivariable analyses. Results: The final cohort included 167 dyads. Poor patient performance status resulted in patient difficulty with mental tasks, more caregiving tasks, and increased caregiving time. Language problems were reported in patients with left-sided lesions. Patient confusion was negatively associated with all caregiver domains: emotional health, social health, general health, ability to work, confidence in finances, and overall QoL. Better caregiver QoL was observed in patients with frontal lobe lesions versus non-frontal lobe lesions. Conclusion: This study reinforced that patient performance status is a critical clinical factor that significantly affects caregiver burden, caregiving tasks, and caregiver time. Additionally, patient confusion affects multiple facets of caregiver burden/QoL. These results could be used to support guided intervention for caregiver support, customized to the patient experience.
KW - Caregiver
KW - Cognitive dysfunction
KW - GBM
KW - Glioblastoma
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U2 - 10.1007/s00520-021-06514-0
DO - 10.1007/s00520-021-06514-0
M3 - Article
C2 - 34510238
AN - SCOPUS:85114776522
SN - 0941-4355
VL - 30
SP - 1365
EP - 1375
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 2
ER -