Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study

Wendy Wang; Rebecca F. Gottesman; Michelle L. Meyer; Timothy M. Hughes; Kevin J. Sullivan; Dean F. Wong; Kamakshi Lakshminarayan; Pamela L. Lutsey

doi:10.3233/JAD-215671

Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study

Wendy Wang, Rebecca F. Gottesman, Michelle L. Meyer, Timothy M. Hughes, Kevin J. Sullivan, Dean F. Wong, Kamakshi Lakshminarayan, Pamela L. Lutsey

Epidemiology

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Abstract

We assessed whether carotid intima-media thickness (cIMT) is prospectively associated with amyloid-β (Aβ). 332 nondemented Atherosclerosis Risk in Communities Study participants with carotid ultrasounds (1990-1992) and PET scans (2012-2014) were studied. Participants in the highest (versus lowest) cIMT tertile had 2.17 times the odds of elevated Aβ (95% CI: 1.15-4.11), after demographic and APOE ϵ4 adjustments. An interaction with APOE ϵ4 was observed (p = 0.02). Greater cIMT was associated with elevated Aβ independent of vascular risk factors among those with ≥1 APOE ϵ4 allele, but not in noncarriers. In this cohort, higher cIMT was associated with Aβ deposition 22 years later, particularly among APOE ϵ4 carriers.

Original language	English (US)
Pages (from-to)	17-22
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	88
Issue number	1
DOIs	https://doi.org/10.3233/JAD-215671
State	Published - 2022

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© 2022-IOS Press. All rights reserved.

Keywords

Alzheimer's disease
amyloid-β
carotid intima-media thickness
carotid ultrasound
florbetapir PET

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study",

abstract = "We assessed whether carotid intima-media thickness (cIMT) is prospectively associated with amyloid-β (Aβ). 332 nondemented Atherosclerosis Risk in Communities Study participants with carotid ultrasounds (1990-1992) and PET scans (2012-2014) were studied. Participants in the highest (versus lowest) cIMT tertile had 2.17 times the odds of elevated Aβ (95% CI: 1.15-4.11), after demographic and APOE ϵ4 adjustments. An interaction with APOE ϵ4 was observed (p = 0.02). Greater cIMT was associated with elevated Aβ independent of vascular risk factors among those with ≥1 APOE ϵ4 allele, but not in noncarriers. In this cohort, higher cIMT was associated with Aβ deposition 22 years later, particularly among APOE ϵ4 carriers.",

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AU - Meyer, Michelle L.

AU - Hughes, Timothy M.

AU - Sullivan, Kevin J.

AU - Wong, Dean F.

AU - Lakshminarayan, Kamakshi

AU - Lutsey, Pamela L.

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KW - florbetapir PET

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Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study

Abstract

Bibliographical note

Keywords

UN SDGs

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