Abstract
This study examines the effect of castration and androgen replacement on [125I]MK801 binding in the hippocampus. In castrated male rats, [125I]MK801 binding was significantly increased in both the stratum oriens and radiatum and the pyramidal cell layer of CA1. In contrast, no increase in [125I]MK801 binding was observed in the stratum oriens and radiatum of CA1 of castrated rats that were treated with dihydrotestosterone. No change in [125I]MK801 binding was observed in the CA3 region or dentate gyrus after castration. The observed increase in [125I]MK801 binding in pyramidal cell neurons within CA1 suggests that androgens may potentially affect hippocampal function by modulating pyramidal cell NMDA receptors.
Original language | English (US) |
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Pages (from-to) | 270-274 |
Number of pages | 5 |
Journal | Brain Research |
Volume | 683 |
Issue number | 2 |
DOIs | |
State | Published - Jun 19 1995 |
Bibliographical note
Funding Information:This work was supported by NIH grants DA06682 and NS 31318 to A.J.B. and NSF-BNS9109226 to R.J.H. We thank Jennifer J. Sanderson for her excellent technical assistance.
Keywords
- Androgen
- Autoradiography
- CA1
- Castration
- Hippocampus
- MK801
- N-Methyl-d-aspartate
- Testosterone