Cell Reprogramming for Regeneration and Repair of the Nervous System

Isaac H. Clark; Alex Roman; Emily Fellows; Swathi Radha; Susanna R. Var; Zachary Roushdy; Samuel M. Borer; Samantha Johnson; Olivia Chen; Jacob S. Borgida; Aleta Steevens; Anala Shetty; Phoebe Strell; Walter C. Low; Andrew W. Grande

doi:10.3390/biomedicines10102598

Cell Reprogramming for Regeneration and Repair of the Nervous System

Isaac H. Clark, Alex Roman, Emily Fellows, Swathi Radha, Susanna R. Var, Zachary Roushdy, Samuel M. Borer, Samantha Johnson, Olivia Chen, Jacob S. Borgida, Aleta Steevens, Anala Shetty, Phoebe Strell, Walter C. Low, Andrew W. Grande

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various cell types through cellular reprogramming of native cells as a promising therapy to replenish lost or diminished cell populations in various neurological diseases. This review provides an in-depth analysis of the current viral vectors, genes of interest, and target cellular populations that have been studied, as well as the challenges and future directions of these novel therapies. Furthermore, the mechanisms by which cellular reprogramming could be optimized as treatment in neurological diseases and a review of the most recent cellular reprogramming in vitro and in vivo studies will also be discussed.

Original language	English (US)
Article number	2598
Journal	Biomedicines
Volume	10
Issue number	10
DOIs	https://doi.org/10.3390/biomedicines10102598
State	Published - Oct 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

Keywords

cell-reprograming
gene therapies
neuro-regeneration

PubMed: MeSH publication types

Journal Article
Review

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title = "Cell Reprogramming for Regeneration and Repair of the Nervous System",

abstract = "A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various cell types through cellular reprogramming of native cells as a promising therapy to replenish lost or diminished cell populations in various neurological diseases. This review provides an in-depth analysis of the current viral vectors, genes of interest, and target cellular populations that have been studied, as well as the challenges and future directions of these novel therapies. Furthermore, the mechanisms by which cellular reprogramming could be optimized as treatment in neurological diseases and a review of the most recent cellular reprogramming in vitro and in vivo studies will also be discussed.",

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doi = "10.3390/biomedicines10102598",

language = "English (US)",

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AU - Clark, Isaac H.

AU - Roman, Alex

AU - Fellows, Emily

AU - Radha, Swathi

AU - Var, Susanna R.

AU - Roushdy, Zachary

AU - Borer, Samuel M.

AU - Johnson, Samantha

AU - Chen, Olivia

AU - Borgida, Jacob S.

AU - Steevens, Aleta

AU - Shetty, Anala

AU - Strell, Phoebe

AU - Low, Walter C.

AU - Grande, Andrew W.

PY - 2022/10

Y1 - 2022/10

N2 - A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various cell types through cellular reprogramming of native cells as a promising therapy to replenish lost or diminished cell populations in various neurological diseases. This review provides an in-depth analysis of the current viral vectors, genes of interest, and target cellular populations that have been studied, as well as the challenges and future directions of these novel therapies. Furthermore, the mechanisms by which cellular reprogramming could be optimized as treatment in neurological diseases and a review of the most recent cellular reprogramming in vitro and in vivo studies will also be discussed.

AB - A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various cell types through cellular reprogramming of native cells as a promising therapy to replenish lost or diminished cell populations in various neurological diseases. This review provides an in-depth analysis of the current viral vectors, genes of interest, and target cellular populations that have been studied, as well as the challenges and future directions of these novel therapies. Furthermore, the mechanisms by which cellular reprogramming could be optimized as treatment in neurological diseases and a review of the most recent cellular reprogramming in vitro and in vivo studies will also be discussed.

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KW - gene therapies

KW - neuro-regeneration

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JO - Biomedicines

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Cell Reprogramming for Regeneration and Repair of the Nervous System

Abstract

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Keywords

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