Abstract
Mobilization agents can be used to stimulate normal donors for the collection of hematopoietic stem and progenitor cells, which can be used for transplantation, gene therapy, and regenerative medicine. Nonmobilized mononuclear cell collections can also be used for immune cell therapies, including genetically modified therapies such as chimeric antigen receptor T-cells. This chapter focuses on cell therapies derived from hematopoietic cells. The marrow product may be subjected to red cell or plasma depletion, cryopreservation, or other cellular engineering procedures. Umbilical cord blood can be collected in the delivery room immediately after the cord is clamped and while the placenta remains in the uterus, or after delivery when the placenta is taken to a nearby laboratory for collection. Adoptive immunotherapy has been used to treat malignancy, viral diseases, diseases with altered immunity, or autoimmune diseases.
| Original language | English (US) |
|---|---|
| Title of host publication | Transfusion Medicine |
| Subtitle of host publication | Fifth Edition |
| Publisher | Wiley |
| Pages | 477-499 |
| Number of pages | 23 |
| ISBN (Electronic) | 9781119599586 |
| ISBN (Print) | 9781119599531 |
| DOIs | |
| State | Published - Jan 1 2021 |
Bibliographical note
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