Cerebellar Coordination of Neuronal Communication in Cerebral Cortex

Samuel S. McAfee; Yu Liu; Roy V. Sillitoe; Detlef H. Heck

doi:10.3389/fnsys.2021.781527

Cerebellar Coordination of Neuronal Communication in Cerebral Cortex

Samuel S. McAfee, Yu Liu, Roy V. Sillitoe, Detlef H. Heck

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Cognitive processes involve precisely coordinated neuronal communications between multiple cerebral cortical structures in a task specific manner. Rich new evidence now implicates the cerebellum in cognitive functions. There is general agreement that cerebellar cognitive function involves interactions between the cerebellum and cerebral cortical association areas. Traditional views assume reciprocal interactions between one cerebellar and one cerebral cortical site, via closed-loop connections. We offer evidence supporting a new perspective that assigns the cerebellum the role of a coordinator of communication. We propose that the cerebellum participates in cognitive function by modulating the coherence of neuronal oscillations to optimize communications between multiple cortical structures in a task specific manner.

Original language	English (US)
Article number	781527
Journal	Frontiers in Systems Neuroscience
Volume	15
DOIs	https://doi.org/10.3389/fnsys.2021.781527
State	Published - Jan 11 2022
Externally published	Yes

Bibliographical note

Funding Information:
SM was supported by American Lebanese Syrian Associated Charities, St. Jude Children’s Research Hospital. DH and YL were supported by R01MH112143, R01MH112143-02S1, and R37MH085726 and the University of Tennessee Neuroscience Institute. RS was supported by R01NS089664, R01NS100874, and 1P50HD103555.

Funding Information:
SM was supported by American Lebanese Syrian Associated Charities, St. Jude Children?s Research Hospital. DH and YL were supported by R01MH112143, R01MH112143-02S1, and R37MH085726 and the University of Tennessee Neuroscience Institute. RS was supported by R01NS089664, R01NS100874, and 1P50HD103555.

Publisher Copyright:
Copyright © 2022 McAfee, Liu, Sillitoe and Heck.

Keywords

cerebellum
cerebrocerebellar communication
cognition
coherence
functional connectivity

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abstract = "Cognitive processes involve precisely coordinated neuronal communications between multiple cerebral cortical structures in a task specific manner. Rich new evidence now implicates the cerebellum in cognitive functions. There is general agreement that cerebellar cognitive function involves interactions between the cerebellum and cerebral cortical association areas. Traditional views assume reciprocal interactions between one cerebellar and one cerebral cortical site, via closed-loop connections. We offer evidence supporting a new perspective that assigns the cerebellum the role of a coordinator of communication. We propose that the cerebellum participates in cognitive function by modulating the coherence of neuronal oscillations to optimize communications between multiple cortical structures in a task specific manner.",

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Cerebellar Coordination of Neuronal Communication in Cerebral Cortex

Abstract

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