Ceric ammonium nitrate (CAN) catalyzed ring cleavage of N-tosyl aziridines: A potential tool for solution phase library generation

S. Chandrasekhar; Ch Narsihmulu; S. Shameem Sultana

doi:10.1016/S0040-4039(02)01718-5

Ceric ammonium nitrate (CAN) catalyzed ring cleavage of N-tosyl aziridines: A potential tool for solution phase library generation

S. Chandrasekhar, Ch Narsihmulu, S. Shameem Sultana

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A range of N-tosylaziridines is cleaved with NaN₃, H₂O, MeOH to synthesize vicinal azidoamines, aminols and amino ethers in good to excellent yields catalyzed by ceric ammonium nitrate and used in solution phase library synthesis.

Original language	English (US)
Pages (from-to)	7361-7363
Number of pages	3
Journal	Tetrahedron Letters
Volume	43
Issue number	41
DOIs	https://doi.org/10.1016/S0040-4039(02)01718-5
State	Published - Oct 7 2002
Externally published	Yes

Bibliographical note

Funding Information:
Two of us, C.N. and S.S.S., are thankful to CSIR, New Delhi for financial assistance.

Keywords

Ceric ammonium nitrate
Cleavage
HO
MeOH
N-substituted aziridines
NaN
Solution phase library
Vicinal azidoamines

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title = "Ceric ammonium nitrate (CAN) catalyzed ring cleavage of N-tosyl aziridines: A potential tool for solution phase library generation",

abstract = "A range of N-tosylaziridines is cleaved with NaN3, H2O, MeOH to synthesize vicinal azidoamines, aminols and amino ethers in good to excellent yields catalyzed by ceric ammonium nitrate and used in solution phase library synthesis.",

keywords = "Ceric ammonium nitrate, Cleavage, HO, MeOH, N-substituted aziridines, NaN, Solution phase library, Vicinal azidoamines",

author = "S. Chandrasekhar and Ch Narsihmulu and {Shameem Sultana}, S.",

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T2 - A potential tool for solution phase library generation

AU - Chandrasekhar, S.

AU - Narsihmulu, Ch

AU - Shameem Sultana, S.

N1 - Funding Information: Two of us, C.N. and S.S.S., are thankful to CSIR, New Delhi for financial assistance.

PY - 2002/10/7

Y1 - 2002/10/7

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AB - A range of N-tosylaziridines is cleaved with NaN3, H2O, MeOH to synthesize vicinal azidoamines, aminols and amino ethers in good to excellent yields catalyzed by ceric ammonium nitrate and used in solution phase library synthesis.

KW - Ceric ammonium nitrate

KW - Cleavage

KW - HO

KW - MeOH

KW - N-substituted aziridines

KW - NaN

KW - Solution phase library

KW - Vicinal azidoamines

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JF - Tetrahedron Letters

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Ceric ammonium nitrate (CAN) catalyzed ring cleavage of N-tosyl aziridines: A potential tool for solution phase library generation

Abstract

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Keywords

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