TY - JOUR
T1 - Cervicovaginal tissue residence confers a distinct differentiation program upon memory CD8 T cells
AU - Davé, Veronica A.
AU - Cardozo-Ojeda, E. Fabian
AU - Mair, Florian
AU - Erickson, Jami
AU - Woodward-Davis, Amanda S.
AU - Koehne, Amanda
AU - Soerens, Andrew
AU - Czartoski, Julie
AU - Teague, Candice
AU - Potchen, Nicole
AU - Oberle, Susanne
AU - Zehn, Dietmar
AU - Schiffer, Joshua T.
AU - Lund, Jennifer M.
AU - Prlic, Martin
N1 - Publisher Copyright:
Copyright © 2021 by The American Association of Immunologists, Inc.
PY - 2021/6/15
Y1 - 2021/6/15
N2 - Tissue-resident memory CD8 T cells (CD8 TRM) are critical for maintaining barrier immunity. CD8 TRM have been mainly studied in the skin, lung and gut, with recent studies suggesting that the signals that control tissue residence and phenotype are highly tissue dependent. We examined the T cell compartment in healthy human cervicovaginal tissue (CVT) and found that most CD8 T cells were granzyme B+ and TCF-1-. To address if this phenotype is driven by CVT tissue residence, we used a mouse model to control for environmental factors. Using localized and systemic infection models, we found that CD8 TRM in the mouse CVT gradually acquired a granzyme B+, TCF-1-phenotype as seen in human CVT. In contrast to CD8 TRM in the gut, these CD8 TRM were not stably maintained regardless of the initial infection route, which led to reductions in local immunity. Our data show that residence in the CVT is sufficient to progressively shape the size and function of its CD8 TRM compartment.
AB - Tissue-resident memory CD8 T cells (CD8 TRM) are critical for maintaining barrier immunity. CD8 TRM have been mainly studied in the skin, lung and gut, with recent studies suggesting that the signals that control tissue residence and phenotype are highly tissue dependent. We examined the T cell compartment in healthy human cervicovaginal tissue (CVT) and found that most CD8 T cells were granzyme B+ and TCF-1-. To address if this phenotype is driven by CVT tissue residence, we used a mouse model to control for environmental factors. Using localized and systemic infection models, we found that CD8 TRM in the mouse CVT gradually acquired a granzyme B+, TCF-1-phenotype as seen in human CVT. In contrast to CD8 TRM in the gut, these CD8 TRM were not stably maintained regardless of the initial infection route, which led to reductions in local immunity. Our data show that residence in the CVT is sufficient to progressively shape the size and function of its CD8 TRM compartment.
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U2 - 10.4049/jimmunol.2100166
DO - 10.4049/jimmunol.2100166
M3 - Article
C2 - 34088770
AN - SCOPUS:85108727746
SN - 0022-1767
VL - 206
SP - 2937
EP - 2948
JO - Journal of Immunology
JF - Journal of Immunology
IS - 12
ER -
