TY - JOUR
T1 - Change in Health-Related Quality of Life in Youth with Chronic Hepatitis B Living in North America
T2 - A 5-Year Cohort Study
AU - Schwarzenberg, Sarah Jane
AU - King, Wendy C.
AU - Ling, Simon C.
AU - Murray, Karen F.
AU - Mogul, Douglas
AU - Rosenthal, Philip
AU - Rodriguez-Baez, Norberto
AU - Teckman, Jeffrey
AU - Schwarz, Kathleen B.
AU - Li, Hongxia
AU - Anders, Robert
AU - Imteyaz, Hejab
AU - Lee, Peter
AU - Oshima, Kiyoko
AU - Kafka, Kim
AU - Islam, Naureen
AU - Swim, Shannon R.
AU - Nagy, Rosemary A.
AU - Cerkoski, Jacki
AU - Hau, Athena
AU - Yuan, Caitlin
AU - Swan, Rosemary
AU - O'Connor, Constance
AU - Rodgers-Augustyniak, Laurie A.
AU - Montanye, Shirley
AU - Feier, Natasha
AU - Feier, Joel
AU - Fleck, Shannon
AU - Langlois, Camille
AU - Cooper, Kara L.
AU - Hoofnagle, Jay H.
AU - Sherker, Averell H.
AU - Doo, Edward
AU - Torrance, Rebecca J.
AU - Hall, Sherry R.
AU - Averbach, Frani
AU - Haller, Tamara
AU - Kelley, Stephanie
AU - Lalama, Christina M.
AU - Lawlor, Sharon
AU - Lin, Hsing Hua S.
AU - Lombardero, Manuel
AU - Pelesko, Andrew
AU - Stoliker, Donna
AU - Weiner, Melissa
AU - Zadorozny, Ella
N1 - Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Background: Greater hepatitis-related symptomology is associated with lower health-related quality-of-life (HRQoL) among untreated youth with chronic hepatitis B (CHB). How HRQoL changes over time in this population is unknown. Methods: Children from 7 hepatology centers in North America positive for hepatitis B surface antigen, not taking anti-viral therapy, were enrolled in the Hepatitis B Research Network. A validated self-report HRQoL measure, the Child Health Questionnaire Child Report (CHQ-CF87), was completed annually by participants 10-17 years, with demographic variables, liver disease symptoms, and laboratory tests. Linear mixed-effects models were used to evaluate the 10 CHQ-CF87 subscale scores over 5 years among participants who completed the CHQ-CF87 at least twice. Results: Participants (N = 174) completed the CHQ-CF87 a median of 4 times. Median age was 12 years (interquartile range: 10-14) at baseline; 60% were female, 79% Asian, and 47% adopted. The CHQ-CF87 subscale scores were high at baseline (median range: 75.4-100) and did not differ by time point, except for the Family Activities subscale (mean [95% CI]: 82.3 [79.8-84.8] at baseline; 90.8 [86.1-94.6] week 240). Most subscale scores lacked sufficient individual-level variability in change over time to evaluate predictors. Being White versus Asian predicted a more favorable change in Behavior (6.5 [95% CI: 2.0-11.0]). Older age predicted less favorable change in Mental Health (-0.8 [95% CI: -1.36 to -0.23] per year). Changes in liver enzymes and hepatitis B antigens, DNA, or symptom count were not related to changes in these subscale scores. Conclusion: HRQoL was generally good and consistent across 5 years in youth with CHB.
AB - Background: Greater hepatitis-related symptomology is associated with lower health-related quality-of-life (HRQoL) among untreated youth with chronic hepatitis B (CHB). How HRQoL changes over time in this population is unknown. Methods: Children from 7 hepatology centers in North America positive for hepatitis B surface antigen, not taking anti-viral therapy, were enrolled in the Hepatitis B Research Network. A validated self-report HRQoL measure, the Child Health Questionnaire Child Report (CHQ-CF87), was completed annually by participants 10-17 years, with demographic variables, liver disease symptoms, and laboratory tests. Linear mixed-effects models were used to evaluate the 10 CHQ-CF87 subscale scores over 5 years among participants who completed the CHQ-CF87 at least twice. Results: Participants (N = 174) completed the CHQ-CF87 a median of 4 times. Median age was 12 years (interquartile range: 10-14) at baseline; 60% were female, 79% Asian, and 47% adopted. The CHQ-CF87 subscale scores were high at baseline (median range: 75.4-100) and did not differ by time point, except for the Family Activities subscale (mean [95% CI]: 82.3 [79.8-84.8] at baseline; 90.8 [86.1-94.6] week 240). Most subscale scores lacked sufficient individual-level variability in change over time to evaluate predictors. Being White versus Asian predicted a more favorable change in Behavior (6.5 [95% CI: 2.0-11.0]). Older age predicted less favorable change in Mental Health (-0.8 [95% CI: -1.36 to -0.23] per year). Changes in liver enzymes and hepatitis B antigens, DNA, or symptom count were not related to changes in these subscale scores. Conclusion: HRQoL was generally good and consistent across 5 years in youth with CHB.
KW - behavioral health
KW - children
KW - mental health
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UR - http://www.scopus.com/inward/citedby.url?scp=85178572363&partnerID=8YFLogxK
U2 - 10.1097/MPG.0000000000003957
DO - 10.1097/MPG.0000000000003957
M3 - Article
C2 - 37756340
AN - SCOPUS:85178572363
SN - 0277-2116
VL - 77
SP - 713
EP - 719
JO - Journal of pediatric gastroenterology and nutrition
JF - Journal of pediatric gastroenterology and nutrition
IS - 6
ER -