TY - JOUR
T1 - Changes in refractive errors in albinism
T2 - a longitudinal study over the first decade of life
AU - Schweigert, Anna
AU - Lunos, Scott
AU - Connett, John
AU - Summers, C. Gail
N1 - Publisher Copyright:
© 2018 American Association for Pediatric Ophthalmology and Strabismus
PY - 2018/12
Y1 - 2018/12
N2 - Purpose: To analyze longitudinal changes in refraction in patients with albinism. Methods: The medical records of 481 patients were reviewed retrospectively to identify patients who had cycloplegic refractions at three ages: visit A, 0-18 months old; visit B, 4-6 years old; visit C, 8-10 years old. We recorded refraction, type of albinism, glasses wear, and best-corrected visual acuity at visit C. Only right eyes were analyzed. Results: A total of 75 patients were included. Of these, 73 wore glasses. Mean best-corrected visual acuity at visit C was 20/72 (range, 20/25-20/200). Mean spherical equivalent was 2.81 ± 2.4 D at visit A, 2.53 ± 3.4 D at visit B, and 2.15 ± 4.0 D at visit C. These values did not differ significantly from visits A to C (P = 0.0578). Mean astigmatism for the three time points was 1.60 ± 1.00 D, 2.50 ± 1.14 D, and 2.87 ± 1.45 D; these values did differ significantly from A to C (P < 0.0001). Subgroup analysis for OCA1A (16 eyes), OCA1B (20 eyes), and OCA2 (30 eyes) showed an increase in astigmatism from A to C, with a significant difference in means (P < 0.0001, P < 0.0001, and P = 0.0001, resp.). Worse best-corrected visual acuity and higher mean astigmatism at visit C were found for OCA1A (20/104 and +4.08 ± 1.34) compared to OCA1B (20/59 and +2.30 ± 1.36; P < 0.0001) and OCA2 (20/66 and +2.53 ±1.21; P < 0.0001). Conclusions: Children with albinism require periodic cycloplegic refraction, because astigmatism often increases within the first 10 years of life.
AB - Purpose: To analyze longitudinal changes in refraction in patients with albinism. Methods: The medical records of 481 patients were reviewed retrospectively to identify patients who had cycloplegic refractions at three ages: visit A, 0-18 months old; visit B, 4-6 years old; visit C, 8-10 years old. We recorded refraction, type of albinism, glasses wear, and best-corrected visual acuity at visit C. Only right eyes were analyzed. Results: A total of 75 patients were included. Of these, 73 wore glasses. Mean best-corrected visual acuity at visit C was 20/72 (range, 20/25-20/200). Mean spherical equivalent was 2.81 ± 2.4 D at visit A, 2.53 ± 3.4 D at visit B, and 2.15 ± 4.0 D at visit C. These values did not differ significantly from visits A to C (P = 0.0578). Mean astigmatism for the three time points was 1.60 ± 1.00 D, 2.50 ± 1.14 D, and 2.87 ± 1.45 D; these values did differ significantly from A to C (P < 0.0001). Subgroup analysis for OCA1A (16 eyes), OCA1B (20 eyes), and OCA2 (30 eyes) showed an increase in astigmatism from A to C, with a significant difference in means (P < 0.0001, P < 0.0001, and P = 0.0001, resp.). Worse best-corrected visual acuity and higher mean astigmatism at visit C were found for OCA1A (20/104 and +4.08 ± 1.34) compared to OCA1B (20/59 and +2.30 ± 1.36; P < 0.0001) and OCA2 (20/66 and +2.53 ±1.21; P < 0.0001). Conclusions: Children with albinism require periodic cycloplegic refraction, because astigmatism often increases within the first 10 years of life.
UR - http://www.scopus.com/inward/record.url?scp=85056451975&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056451975&partnerID=8YFLogxK
U2 - 10.1016/j.jaapos.2018.08.005
DO - 10.1016/j.jaapos.2018.08.005
M3 - Article
C2 - 30343058
AN - SCOPUS:85056451975
SN - 1091-8531
VL - 22
SP - 462
EP - 466
JO - Journal of AAPOS
JF - Journal of AAPOS
IS - 6
ER -