Abstract
We studied the relationship between CALLA + thymocytes and two known markers of T-lymphocyte differentiation, Tdt and the sheep erythrocyte receptor. Thymocytes were studied using double fluorochrome analysis (with monoclonal anti-CALLA antibody and anti-Tdt) before and after E rosette separation. We found that approx. 4% of unseparated thymocytes were CALLA + and that most CALLA + cells were also Tdt+. After E rosettes separation CALLA + Tdt + cells were found mostly in the ER- fraction (20% of ER- cells) while only 1.0% of ER + cells were CALLA +. The expression of CALLA on ER- Tdt + thymocytes suggests that CALLA may defined cells early in T-cell differentiation.
Original language | English (US) |
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Pages (from-to) | 173-175,177-179 |
Journal | Leukemia research |
Volume | 8 |
Issue number | 2 |
DOIs | |
State | Published - 1984 |
Keywords
- Common acute lymphoblastic leukemia antigen
- prothymocyte
- terminal deoxynucleotidyl transferase