Cholangiopathies and the noncoding revolution

Sergio Gradilone; Nicola Brunetti-Pierri; Pasquale Piccolo

doi:10.1097/MOG.0000000000000806

Cholangiopathies and the noncoding revolution

Sergio Gradilone, Nicola Brunetti-Pierri, Pasquale Piccolo

Hormel Institute

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of reviewNoncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) among others, have attracted a great deal of attention for their potential role as master regulators of gene expression and as therapeutic targets. This review focuses on recent advances on the role of ncRNAs in the pathogenesis, diagnosis and treatment of diseases of the cholangiocytes (i.e. cholangiopathies).Recent findingsIn the recent years, there has been an exponential growth in the knowledge on ncRNAs and their role in cholangiopathies, particularly cholangiocarcinoma.SummaryAlthough several studies focused on miRNAs as noninvasive biomarkers for diagnosis and staging, several studies also highlighted their functions and provided new insights into disease mechanisms.

Original language	English (US)
Pages (from-to)	128-135
Number of pages	8
Journal	Current opinion in gastroenterology
Volume	38
Issue number	2
DOIs	https://doi.org/10.1097/MOG.0000000000000806
State	Published - Mar 1 2022

Bibliographical note

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© 2022 Lippincott Williams and Wilkins. All rights reserved.

Keywords

biliary diseases
cholangiocarcinoma
cholangiopathies
microRNA

PubMed: MeSH publication types

Journal Article
Review

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Cholangiopathies and the noncoding revolution

Abstract

Bibliographical note

Keywords

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