Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice

A. Bartolomucci; A. E. Rigamonti; I. Bulgarelli; A. Torsello; V. Locatelli; F. Pavone; A. Levi; R. Possenti; E. E. Muller; A. Moles

doi:10.1016/j.ghir.2007.02.002

Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice

A. Bartolomucci, A. E. Rigamonti, I. Bulgarelli, A. Torsello, V. Locatelli, F. Pavone, A. Levi, R. Possenti, E. E. Muller, A. Moles

Integrative Biology and Physiology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Objective: Biallelic ablation of VGF determines a dwarf phenotype. VGF precursor protein encodes for different biologically active peptides none of which has been related to growth or muscular abnormalities. Here we present the first attempt to fill this gap. We tested the hypothesis that a recently identified VGF-derived peptide, TLQP-21, shown to centrally modulate metabolic functions, could also modulate growth hormone (GH)-axis and muscle strength. Design: Adult male mice were chronically icv injected with TLQP-21 (15 μg/day for 14 days). Physiological, molecular and behavioral parameters related to the GH/IGF-1-axis were investigated. Results: Except for a reduction in the soleus weight, TLQP-21 did not affect GH/IGF-1-axis mediators, muscle strength and muscle weight. Conclusions: Results collected exclude a role for TLQP-21 in modulating the GH/IGF1-axis and muscle functions. VGF-derived peptides involved in the dwarf phenotype of VGF-/- mice have to be identified yet.

Original language	English (US)
Pages (from-to)	342-345
Number of pages	4
Journal	Growth Hormone and IGF Research
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.ghir.2007.02.002
State	Published - Aug 2007

Keywords

GH
GHRH
Grip strength test
IGF-1
Soleus
Somatostatin
VGF

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title = "Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice",

abstract = "Objective: Biallelic ablation of VGF determines a dwarf phenotype. VGF precursor protein encodes for different biologically active peptides none of which has been related to growth or muscular abnormalities. Here we present the first attempt to fill this gap. We tested the hypothesis that a recently identified VGF-derived peptide, TLQP-21, shown to centrally modulate metabolic functions, could also modulate growth hormone (GH)-axis and muscle strength. Design: Adult male mice were chronically icv injected with TLQP-21 (15 μg/day for 14 days). Physiological, molecular and behavioral parameters related to the GH/IGF-1-axis were investigated. Results: Except for a reduction in the soleus weight, TLQP-21 did not affect GH/IGF-1-axis mediators, muscle strength and muscle weight. Conclusions: Results collected exclude a role for TLQP-21 in modulating the GH/IGF1-axis and muscle functions. VGF-derived peptides involved in the dwarf phenotype of VGF-/- mice have to be identified yet.",

keywords = "GH, GHRH, Grip strength test, IGF-1, Soleus, Somatostatin, VGF",

author = "A. Bartolomucci and Rigamonti, {A. E.} and I. Bulgarelli and A. Torsello and V. Locatelli and F. Pavone and A. Levi and R. Possenti and Muller, {E. E.} and A. Moles",

year = "2007",

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doi = "10.1016/j.ghir.2007.02.002",

language = "English (US)",

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T1 - Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice

AU - Bartolomucci, A.

AU - Rigamonti, A. E.

AU - Bulgarelli, I.

AU - Torsello, A.

AU - Locatelli, V.

AU - Pavone, F.

AU - Levi, A.

AU - Possenti, R.

AU - Muller, E. E.

AU - Moles, A.

PY - 2007/8

Y1 - 2007/8

N2 - Objective: Biallelic ablation of VGF determines a dwarf phenotype. VGF precursor protein encodes for different biologically active peptides none of which has been related to growth or muscular abnormalities. Here we present the first attempt to fill this gap. We tested the hypothesis that a recently identified VGF-derived peptide, TLQP-21, shown to centrally modulate metabolic functions, could also modulate growth hormone (GH)-axis and muscle strength. Design: Adult male mice were chronically icv injected with TLQP-21 (15 μg/day for 14 days). Physiological, molecular and behavioral parameters related to the GH/IGF-1-axis were investigated. Results: Except for a reduction in the soleus weight, TLQP-21 did not affect GH/IGF-1-axis mediators, muscle strength and muscle weight. Conclusions: Results collected exclude a role for TLQP-21 in modulating the GH/IGF1-axis and muscle functions. VGF-derived peptides involved in the dwarf phenotype of VGF-/- mice have to be identified yet.

AB - Objective: Biallelic ablation of VGF determines a dwarf phenotype. VGF precursor protein encodes for different biologically active peptides none of which has been related to growth or muscular abnormalities. Here we present the first attempt to fill this gap. We tested the hypothesis that a recently identified VGF-derived peptide, TLQP-21, shown to centrally modulate metabolic functions, could also modulate growth hormone (GH)-axis and muscle strength. Design: Adult male mice were chronically icv injected with TLQP-21 (15 μg/day for 14 days). Physiological, molecular and behavioral parameters related to the GH/IGF-1-axis were investigated. Results: Except for a reduction in the soleus weight, TLQP-21 did not affect GH/IGF-1-axis mediators, muscle strength and muscle weight. Conclusions: Results collected exclude a role for TLQP-21 in modulating the GH/IGF1-axis and muscle functions. VGF-derived peptides involved in the dwarf phenotype of VGF-/- mice have to be identified yet.

KW - GH

KW - GHRH

KW - Grip strength test

KW - IGF-1

KW - Soleus

KW - Somatostatin

KW - VGF

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Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice

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