TY - JOUR
T1 - Chronobiology and chronomics honor Douglas Wilson. neither calories nor anything else are equal at breakfast and dinner or along other time scales
AU - Cornelissen-Guillaume, Germaine G
AU - Singh, R. B.
AU - Schwartzkopff, Othild
AU - Halberg, Franz
PY - 2013
Y1 - 2013
N2 - To honor Douglas Wilson, this paper reviews evidence for studying and quantifying rhythms as the indispensable control, whether to assess the effect of a fixed-calorie meal taken as breakfast or dinner, or to understand how human physiology and pathology may be affected by space-terrestrial weather. Since D. Wilson's work has dealt intensively with salivary hormonal determinations, we illustrate what can be learned from longitudinal series obtained in health or from a patient suffering from adynamic depression episodes recurring twice a year and lasting 2-3 months. The socially less unacceptable collection of serial salivary samples should be introduced more broadly into laboratory medicine for a more refined diagnosis and as a means to guide the optimization of any needed treatment by timing.
AB - To honor Douglas Wilson, this paper reviews evidence for studying and quantifying rhythms as the indispensable control, whether to assess the effect of a fixed-calorie meal taken as breakfast or dinner, or to understand how human physiology and pathology may be affected by space-terrestrial weather. Since D. Wilson's work has dealt intensively with salivary hormonal determinations, we illustrate what can be learned from longitudinal series obtained in health or from a patient suffering from adynamic depression episodes recurring twice a year and lasting 2-3 months. The socially less unacceptable collection of serial salivary samples should be introduced more broadly into laboratory medicine for a more refined diagnosis and as a means to guide the optimization of any needed treatment by timing.
KW - Chronobiology
KW - Chronomics
KW - Circadian stage-dependent response
KW - Isocaloric meal
KW - Relative weight loss
KW - Salivary hormonal determinations
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U2 - 10.2174/1876396001306010089
DO - 10.2174/1876396001306010089
M3 - Review article
AN - SCOPUS:84902985568
SN - 1876-3960
VL - 6
SP - 89
EP - 104
JO - Open Nutraceuticals Journal
JF - Open Nutraceuticals Journal
IS - SPEC.ISS.1
ER -