TY - JOUR
T1 - Chrosomal organization of the human major histocompatibility complex class I gene family
AU - Koller, B. H.
AU - Geraghty, D. E.
AU - DeMars, R.
AU - Duvick, L.
AU - Rich, S. S.
AU - Orr, H. T.
PY - 1989
Y1 - 1989
N2 - 17 HLA class I genes have been isolated from the genome of B-lymphoblastoid cell line 721. Sequence analysis and transfection studies indicate that three genes, in addition to those encoding the HLA-A, -B, and -C antigens can direct the synthesis of a class I α protein. Using gene-specific DNA probes to analyze the presence of restriction fragment-length polymorphisms within a large pedigree and in panel of HLA deletion mutant cell lines, we show that two of these genes, designated HLA-G and HLA-F, are lcoated on the short arm of chromosome 6 telomeric to the HLA-A locus. The third expressed non-A, -B, and -C class I gene, HLA-E, is located between HLA-A and HLA-C. In addition, the remaining 11 class I pseudogenes and gene fragments are localized relative to established markers on chromosome 6p.
AB - 17 HLA class I genes have been isolated from the genome of B-lymphoblastoid cell line 721. Sequence analysis and transfection studies indicate that three genes, in addition to those encoding the HLA-A, -B, and -C antigens can direct the synthesis of a class I α protein. Using gene-specific DNA probes to analyze the presence of restriction fragment-length polymorphisms within a large pedigree and in panel of HLA deletion mutant cell lines, we show that two of these genes, designated HLA-G and HLA-F, are lcoated on the short arm of chromosome 6 telomeric to the HLA-A locus. The third expressed non-A, -B, and -C class I gene, HLA-E, is located between HLA-A and HLA-C. In addition, the remaining 11 class I pseudogenes and gene fragments are localized relative to established markers on chromosome 6p.
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U2 - 10.1084/jem.169.2.469
DO - 10.1084/jem.169.2.469
M3 - Article
C2 - 2562983
AN - SCOPUS:0024476879
SN - 0022-1007
VL - 169
SP - 469
EP - 480
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 2
ER -