Abstract
Background: The chronome (from chronos, time, and nomos, rule), or time structure, of lipid peroxidation and anti-oxidant defense mechanisms may relate to prevention and curative chronochemotherapeutic efficacy and management. Patients and methods: Newly diagnosed women with gynecological malignancies (N=30), 30-60 years of age, and age-matched clinically healthy women (N=35) provided blood samples every 6 hours for 24 hours under standardized conditions. Plasma malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities, and serum ascorbate, urate and high-density lipoprotein cholesterol (HDL-C) concentrations were determined. Results: Each variable underwent circadian variation (p≤0.002). Patients differed from controls by their overall chronome-adjusted mean value (MESOR) and by the circadian dynamics in the spectral element of their chronome. Conclusion: Chronomes of putative anti- and pro-oxidants should be mapped to explore their putative chemotherapeutic role as markers in cancer chronoprevention and management of established disease.
Original language | English (US) |
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Pages (from-to) | 593-600 |
Number of pages | 8 |
Journal | In Vivo |
Volume | 17 |
Issue number | 6 |
State | Published - 2003 |
Keywords
- Anti-oxidant defense mechanisms
- Chronome
- Chronotherapy
- Circadian
- Gynecological cancer
- Lipid peroxidation
- Marker