Circadian phase difference of leptin in android versus gynoid obesity

Federico Perfetto; Roberto Tarquini; Germaine G Cornelissen-Guillaume; Giorgio Mello; Alessio Tempestini; Paola Gaudiano; Francesco Mancuso; Franz Halberg

doi:10.1016/j.peptides.2004.06.005

Circadian phase difference of leptin in android versus gynoid obesity

Federico Perfetto, Roberto Tarquini, Germaine G Cornelissen-Guillaume, Giorgio Mello, Alessio Tempestini, Paola Gaudiano, Francesco Mancuso, Franz Halberg

Physiology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A circadian rhythm in serum leptin, measured every 4 h for 24 h, characterizes normal-weight women (N = 14), and women with gynoid (N = 17) or android (N = 26) obesity, peaking around midnight (P < 0.05), but differing by about 3 h between android and gynoid women (P < 0.01). Obesity is associated with a higher MESOR (rhythm-adjusted mean; P < 0.001) and a smaller relative circadian amplitude (P < 0.05). Gynoid obesity is associated with a larger circadian amplitude of cortisol (P < 0.05), whereas android obesity is associated with a larger circadian amplitude and a higher MESOR of insulin (P < 0.05). Understanding putative mechanisms underlying different body fat distribution may lead to improved chronotherapeutic measures.

Original language	English (US)
Pages (from-to)	1297-1306
Number of pages	10
Journal	Peptides
Volume	25
Issue number	8
DOIs	https://doi.org/10.1016/j.peptides.2004.06.005
State	Published - Aug 2004

Keywords

Body fat distribution (android versus gynoid)
Circadian rhythm
Cortisol
Insulin
Leptin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "A circadian rhythm in serum leptin, measured every 4 h for 24 h, characterizes normal-weight women (N = 14), and women with gynoid (N = 17) or android (N = 26) obesity, peaking around midnight (P < 0.05), but differing by about 3 h between android and gynoid women (P < 0.01). Obesity is associated with a higher MESOR (rhythm-adjusted mean; P < 0.001) and a smaller relative circadian amplitude (P < 0.05). Gynoid obesity is associated with a larger circadian amplitude of cortisol (P < 0.05), whereas android obesity is associated with a larger circadian amplitude and a higher MESOR of insulin (P < 0.05). Understanding putative mechanisms underlying different body fat distribution may lead to improved chronotherapeutic measures.",

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AU - Cornelissen-Guillaume, Germaine G

AU - Mello, Giorgio

AU - Tempestini, Alessio

AU - Gaudiano, Paola

AU - Mancuso, Francesco

AU - Halberg, Franz

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KW - Cortisol

KW - Insulin

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Circadian phase difference of leptin in android versus gynoid obesity

Abstract

Keywords

UN SDGs

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