TY - JOUR
T1 - Circadian variation in the gastric-emptying response to eating in rats previously fed once or twice daily
AU - Trout, David L.
AU - King, Steven A.
AU - Bernstein, Patricia A.
AU - Halberg, Franz
AU - Cornelissen-Guillaume, Germaine G
PY - 1991
Y1 - 1991
N2 - Four experiments dealt with circadian variation in the gastric emptying (GE) response to eating, among rats accustomed to eating once (1X) or twice daily (2x). In measuring GE response, a test meal [10 g accustomed diet per (kg body weight)3/4] was fed close to a scheduled eating time or after a delay of up to 24 h. GE response was the fraction of the ingested test meal emptied per hr, up to a known degree of emptying, e.g., 50-58% of the test meal. Animals accustomed to the prescribed eating patterns ate promptly and at similarly rapid rates at all times of day. GE response, as plotted against time of response, fit a 24-h cosine model. Acrophase (time of maximum GE response of the fitted model) was similar, being 1.5 and 2.1 h, respectively, after the starting time of the accustomed dark-span meal for 1X and 2x rats, while amplitude (1/2 the maximum-to-minimum difference) was 41 and 24% of the MESOR (rhythm-adjusted mean). Characteristics of the GE rhythm appeared to be unchanged among 1X rats, severely versus minimally restricted in food intake during a final 9 days.
AB - Four experiments dealt with circadian variation in the gastric emptying (GE) response to eating, among rats accustomed to eating once (1X) or twice daily (2x). In measuring GE response, a test meal [10 g accustomed diet per (kg body weight)3/4] was fed close to a scheduled eating time or after a delay of up to 24 h. GE response was the fraction of the ingested test meal emptied per hr, up to a known degree of emptying, e.g., 50-58% of the test meal. Animals accustomed to the prescribed eating patterns ate promptly and at similarly rapid rates at all times of day. GE response, as plotted against time of response, fit a 24-h cosine model. Acrophase (time of maximum GE response of the fitted model) was similar, being 1.5 and 2.1 h, respectively, after the starting time of the accustomed dark-span meal for 1X and 2x rats, while amplitude (1/2 the maximum-to-minimum difference) was 41 and 24% of the MESOR (rhythm-adjusted mean). Characteristics of the GE rhythm appeared to be unchanged among 1X rats, severely versus minimally restricted in food intake during a final 9 days.
KW - Caloric restriction
KW - Circadian rhythm
KW - Cosinor model
KW - Eating pattern
KW - Gastric emptying
KW - Gastric emptying rate
KW - Rat
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U2 - 10.3109/07420529109063915
DO - 10.3109/07420529109063915
M3 - Article
C2 - 1814598
AN - SCOPUS:0026035527
SN - 0742-0528
VL - 8
SP - 14
EP - 24
JO - Chronobiology international
JF - Chronobiology international
IS - 1
ER -