Cochlear changes in serous labyrinthitis associated with silent otitis media: A human temporal bone study

Serdar Kaya; Vladimir Tsuprun; Ömer Hizli; Patricia A. Schachern; Michael M. Paparella; Sebahattin Cureoglu

doi:10.1016/j.amjoto.2015.10.002

Cochlear changes in serous labyrinthitis associated with silent otitis media: A human temporal bone study

Serdar Kaya, Vladimir Tsuprun, Ömer Hizli, Patricia A. Schachern, Michael M. Paparella, Sebahattin Cureoglu

Otolaryngology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Purpose To determine histopathological findings in the cochlea of human temporal bones with serous labyrinthitis. Materials and methods We compared human temporal bones with serous labyrinthitis (20 cases) associated with silent otitis media and without serous labyrinthitis (20 cases) to study location of serous labyrinthitis, the degree of endolymphatic hydrops, number of spiral ganglion cells and hair cells, loss of fibrocytes in the spiral ligament, and areas of the spiral ligament and stria vascularis. Results The serous labyrinthitis caused significant loss of outer hair cells in the lower basal (P = 0.006), upper basal (P = 0.005), and lower middle (P = 0.011) cochlear turns, and significant increase in the degree of endolymphatic hydrops than the control group (P = 0.036). No significant difference was found in the loss of inner hair cells, in the number of spiral ganglion cells and fibrocytes in the spiral ligament, and in areas of the stria vascularis and spiral ligament (P > 0.05). Conclusions Serous labyrinthitis resulted in significant loss of outer hair cells and significant increase in the degree of endolymphatic hydrops.

Original language	English (US)
Pages (from-to)	83-88
Number of pages	6
Journal	American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/j.amjoto.2015.10.002
State	Published - Mar 1 2016

Bibliographical note

Funding Information:
Financial disclosure: This project was funded by the National Institute on Deafness and Other Communication Disorders (NIDCD) , grant number U24 DC011968-01 ; the International Hearing Foundation ; the Starkey Hearing Foundation ; the 5M Lions International ; and the Scientific and Technological Research Council of Turkey (TUBITAK) .

Funding Information:
This study was supported by the National Institute on Deafness and Other Communication Disorders (NIDCD), grant number U24 DC011968-01; the International Hearing Foundation; the Starkey Hearing Foundation; the 5M Lions International; and the Scientific and Technological Research Council of Turkey (TUBITAK).

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© 2016 Elsevier Inc. All rights reserved.

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title = "Cochlear changes in serous labyrinthitis associated with silent otitis media: A human temporal bone study",

abstract = "Purpose To determine histopathological findings in the cochlea of human temporal bones with serous labyrinthitis. Materials and methods We compared human temporal bones with serous labyrinthitis (20 cases) associated with silent otitis media and without serous labyrinthitis (20 cases) to study location of serous labyrinthitis, the degree of endolymphatic hydrops, number of spiral ganglion cells and hair cells, loss of fibrocytes in the spiral ligament, and areas of the spiral ligament and stria vascularis. Results The serous labyrinthitis caused significant loss of outer hair cells in the lower basal (P = 0.006), upper basal (P = 0.005), and lower middle (P = 0.011) cochlear turns, and significant increase in the degree of endolymphatic hydrops than the control group (P = 0.036). No significant difference was found in the loss of inner hair cells, in the number of spiral ganglion cells and fibrocytes in the spiral ligament, and in areas of the stria vascularis and spiral ligament (P > 0.05). Conclusions Serous labyrinthitis resulted in significant loss of outer hair cells and significant increase in the degree of endolymphatic hydrops.",

author = "Serdar Kaya and Vladimir Tsuprun and {\"O}mer Hizli and Schachern, {Patricia A.} and Paparella, {Michael M.} and Sebahattin Cureoglu",

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AU - Kaya, Serdar

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AU - Hizli, Ömer

AU - Schachern, Patricia A.

AU - Paparella, Michael M.

AU - Cureoglu, Sebahattin

N1 - Funding Information: Financial disclosure: This project was funded by the National Institute on Deafness and Other Communication Disorders (NIDCD) , grant number U24 DC011968-01 ; the International Hearing Foundation ; the Starkey Hearing Foundation ; the 5M Lions International ; and the Scientific and Technological Research Council of Turkey (TUBITAK) . Funding Information: This study was supported by the National Institute on Deafness and Other Communication Disorders (NIDCD), grant number U24 DC011968-01; the International Hearing Foundation; the Starkey Hearing Foundation; the 5M Lions International; and the Scientific and Technological Research Council of Turkey (TUBITAK). Publisher Copyright: © 2016 Elsevier Inc. All rights reserved.

PY - 2016/3/1

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N2 - Purpose To determine histopathological findings in the cochlea of human temporal bones with serous labyrinthitis. Materials and methods We compared human temporal bones with serous labyrinthitis (20 cases) associated with silent otitis media and without serous labyrinthitis (20 cases) to study location of serous labyrinthitis, the degree of endolymphatic hydrops, number of spiral ganglion cells and hair cells, loss of fibrocytes in the spiral ligament, and areas of the spiral ligament and stria vascularis. Results The serous labyrinthitis caused significant loss of outer hair cells in the lower basal (P = 0.006), upper basal (P = 0.005), and lower middle (P = 0.011) cochlear turns, and significant increase in the degree of endolymphatic hydrops than the control group (P = 0.036). No significant difference was found in the loss of inner hair cells, in the number of spiral ganglion cells and fibrocytes in the spiral ligament, and in areas of the stria vascularis and spiral ligament (P > 0.05). Conclusions Serous labyrinthitis resulted in significant loss of outer hair cells and significant increase in the degree of endolymphatic hydrops.

AB - Purpose To determine histopathological findings in the cochlea of human temporal bones with serous labyrinthitis. Materials and methods We compared human temporal bones with serous labyrinthitis (20 cases) associated with silent otitis media and without serous labyrinthitis (20 cases) to study location of serous labyrinthitis, the degree of endolymphatic hydrops, number of spiral ganglion cells and hair cells, loss of fibrocytes in the spiral ligament, and areas of the spiral ligament and stria vascularis. Results The serous labyrinthitis caused significant loss of outer hair cells in the lower basal (P = 0.006), upper basal (P = 0.005), and lower middle (P = 0.011) cochlear turns, and significant increase in the degree of endolymphatic hydrops than the control group (P = 0.036). No significant difference was found in the loss of inner hair cells, in the number of spiral ganglion cells and fibrocytes in the spiral ligament, and in areas of the stria vascularis and spiral ligament (P > 0.05). Conclusions Serous labyrinthitis resulted in significant loss of outer hair cells and significant increase in the degree of endolymphatic hydrops.

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Cochlear changes in serous labyrinthitis associated with silent otitis media: A human temporal bone study

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