TY - JOUR
T1 - Cochlear stem cells/progenitors and degenerative hearing disorders
AU - Lin, Jizhen
AU - Feng, Ling
AU - Fukudome, Shinji
AU - Hamajima, Yuki
AU - Huang, Tina
AU - Levine, Samuel
PY - 2007/11
Y1 - 2007/11
N2 - Hearing loss (deafness) affects approximately 250 million people globally. The major cause of deafness is loss of hair cells and spiral ganglion neurons due to aging, antibiotic use, noise exposure, and genetic defects. At the present time, there is no effective method for restoration of boring biologically. Cochlear stem cells/progenitors (CSCs), quiescent in die organ of Corti, are excellent candidates for restoration of cell types in the organ of Corti biologically. However, little is known about the biology of CSCs and developmental cues for CSCs to differentiate into hair cells and neurons at the present time. In this article, we briefly reviewed the isolation of CSCs from the postnatal organ of Corti in mice and their capability to differentiate into hair cells and neurons in vitro under the guidance of a group of growth factors: sonic hedgehog (SHH), epidermal growth factor (EGF), retinoic acid (RA), and brain-derived neurotrophic factor (BDNF), herein termed SERB. The identification of CSCs and their differentiation signals is potentially of clinical importance.
AB - Hearing loss (deafness) affects approximately 250 million people globally. The major cause of deafness is loss of hair cells and spiral ganglion neurons due to aging, antibiotic use, noise exposure, and genetic defects. At the present time, there is no effective method for restoration of boring biologically. Cochlear stem cells/progenitors (CSCs), quiescent in die organ of Corti, are excellent candidates for restoration of cell types in the organ of Corti biologically. However, little is known about the biology of CSCs and developmental cues for CSCs to differentiate into hair cells and neurons at the present time. In this article, we briefly reviewed the isolation of CSCs from the postnatal organ of Corti in mice and their capability to differentiate into hair cells and neurons in vitro under the guidance of a group of growth factors: sonic hedgehog (SHH), epidermal growth factor (EGF), retinoic acid (RA), and brain-derived neurotrophic factor (BDNF), herein termed SERB. The identification of CSCs and their differentiation signals is potentially of clinical importance.
UR - http://www.scopus.com/inward/record.url?scp=36749020564&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36749020564&partnerID=8YFLogxK
U2 - 10.2174/092986707782360051
DO - 10.2174/092986707782360051
M3 - Review article
C2 - 18045139
AN - SCOPUS:36749020564
SN - 0929-8673
VL - 14
SP - 2937
EP - 2943
JO - Current medicinal chemistry
JF - Current medicinal chemistry
IS - 27
ER -