Coffee Consumption May Mitigate the Risk for Acute Kidney Injury: Results From the Atherosclerosis Risk in Communities Study

Kalie L. Tommerdahl; Emily A. Hu; Elizabeth Selvin; Lyn M. Steffen; Josef Coresh; Morgan E. Grams; Petter Bjornstad; Casey M. Rebholz; Chirag R. Parikh

doi:10.1016/j.ekir.2022.04.091

Coffee Consumption May Mitigate the Risk for Acute Kidney Injury: Results From the Atherosclerosis Risk in Communities Study

Kalie L. Tommerdahl, Emily A. Hu, Elizabeth Selvin, Lyn M. Steffen, Josef Coresh, Morgan E. Grams, Petter Bjornstad, Casey M. Rebholz, Chirag R. Parikh

Epidemiology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Introduction: Coffee is one of the most frequently consumed beverages worldwide and has been found to have a wide assortment of health benefits. Although habitual coffee consumption is associated with a lower incidence of chronic kidney disease, an association between coffee and acute kidney injury (AKI) has not yet been revealed. Methods: In the Atherosclerosis Risk in Communities (ARIC) Study, a prospective cohort study of 14,207 adults aged 45 to 64 years, coffee consumption (cups/d) was assessed at a single visit via food frequency questionnaires and compared with incident AKI defined by hospitalization with an AKI-related International Classification of Diseases code. Results: In ARIC, there were 1694 cases of incident AKI in a median of 24 follow-up years. Higher coffee consumption was associated with lower AKI risk versus no consumption (hazard ratio [HR] <1 cup/d: 0.92 [95% CI: 0.79–1.08]; 1 cup/d: 1.08 [95% CI: 0.94–1.24]; 2 to 3 cups/d: 0.83 [95% CI: 0.72–0.95]; >3 cups/d: 0.83 [95% CI: 0.71–0.96]; reference: never, P = 0.003). Trends for AKI risk across coffee categories remained significant after multivariable adjustment for age, sex, race-center, education, total daily energy intake, physical activity, smoking, alcohol intake, diet quality (Dietary Approaches to Stop Hypertension [DASH] score), systolic blood pressure (BP), diabetes status, use of antihypertensive agents, estimated glomerular filtration rate (eGFR), and body mass index (BMI) (P = 0.02). Conclusion: Higher coffee intake was associated with a lower risk of incident AKI and could present an opportunity for cardiorenal protection through diet. Further evaluation of the physiological mechanisms underlying the cardiorenal protective effects of coffee consumption is necessary.

Original language	English (US)
Pages (from-to)	1665-1672
Number of pages	8
Journal	Kidney International Reports
Volume	7
Issue number	7
DOIs	https://doi.org/10.1016/j.ekir.2022.04.091
State	Published - Jul 2022

Bibliographical note

Funding Information:
The authors thank the staff and participants of the ARIC study for their important contributions. The ARIC study has been funded in whole or in part with federal funds from the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Department of Health and Human Services, under contract numbers (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I, HHSN268201700005I). KLT receives salary and research support from the NIH/NHLBI (K23 HL159292), Children's Hospital Colorado Research Institute Research Scholar Award, University of Colorado Diabetes Research Center (P30 DK116073), Ludeman Family Center for Women's Health Research at the University of Colorado, ISPAD-JDRF Research Fellowship, and the Department of Pediatrics, Section of Endocrinology at the University of Colorado School of Medicine. CMR was supported by grants from the NIH/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (K01 DK107782, R03 DK128386) and the NIH/NHLBI (R01 HL153178). ES was supported by the NIH/NHLBI (K24 HL152440). PB receives salary and research support from NIDDK (R01 DK129211, R21 DK129720, K23 DK116720, UC DK114886, and P30 DK116073), JDRF (2-SRA-2019-845-S-B, 3-SRA-2017-424-M-B, 3-SRA-2022-1097-M-B), Boettcher Foundation, American Heart Association (20IPA35260142), Ludeman Family Center for Women's Health Research at the University of Colorado, the Department of Pediatrics, Section of Endocrinology and Barbara Davis Center for Diabetes at University of Colorado School of Medicine. CRP is supported by NIH/NHLBI (R01 HL085757) and NIH/NIDDK (UH3 DK114866, U01 DK106962, R01 DK093770). The funders had no role in the study design; collection, analysis, and interpretation of these data; writing the report; or the decision to submit the report. The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as official policy or interpretation of the US government. Trial Registration:, ClinicalTrials.gov NCT00005131 (ARIC). KLT analyzed and interpreted data and wrote the manuscript. EAH, ES, LMS, JC, and MEG contributed to the development of the research idea and study design. EAH analyzed and interpreted the data. PB and CMR analyzed and interpreted the data and contributed to the discussion. CRP designed the study, analyzed and interpreted the data, and contributed to the discussion. All c-oauthors reviewed and edited the manuscript. CRP and CMR are the guarantor of this work and have full access to the data sets and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Funding Information:
The authors thank the staff and participants of the ARIC study for their important contributions. The ARIC study has been funded in whole or in part with federal funds from the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Department of Health and Human Services , under contract numbers (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I, HHSN268201700005I). KLT receives salary and research support from the NIH/NHLBI (K23 HL159292), Children’s Hospital Colorado Research Institute Research Scholar Award, University of Colorado Diabetes Research Center (P30 DK116073), Ludeman Family Center for Women’s Health Research at the University of Colorado, ISPAD-JDRF Research Fellowship, and the Department of Pediatrics, Section of Endocrinology at the University of Colorado School of Medicine . CMR was supported by grants from the NIH/ National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (K01 DK107782, R03 DK128386) and the NIH/NHLBI (R01 HL153178). ES was supported by the NIH / NHLBI (K24 HL152440). PB receives salary and research support from NIDDK (R01 DK129211, R21 DK129720, K23 DK116720, UC DK114886, and P30 DK116073), JDRF (2-SRA-2019-845-S-B, 3-SRA-2017-424-M-B, 3-SRA-2022-1097-M-B), Boettcher Foundation , American Heart Association (20IPA35260142), Ludeman Family Center for Women’s Health Research at the University of Colorado , the Department of Pediatrics, Section of Endocrinology and Barbara Davis Center for Diabetes at University of Colorado School of Medicine . CRP is supported by NIH / NHLBI (R01 HL085757) and NIH / NIDDK (UH3 DK114866, U01 DK106962, R01 DK093770). The funders had no role in the study design; collection, analysis, and interpretation of these data; writing the report; or the decision to submit the report. The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as official policy or interpretation of the US government. Trial Registration:

Publisher Copyright:
© 2022 International Society of Nephrology

Keywords

acute kidney injury
beverages
caffeine
coffee
incident AKI

PubMed: MeSH publication types

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ekir.2022.04.091

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Cite this

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title = "Coffee Consumption May Mitigate the Risk for Acute Kidney Injury: Results From the Atherosclerosis Risk in Communities Study",

abstract = "Introduction: Coffee is one of the most frequently consumed beverages worldwide and has been found to have a wide assortment of health benefits. Although habitual coffee consumption is associated with a lower incidence of chronic kidney disease, an association between coffee and acute kidney injury (AKI) has not yet been revealed. Methods: In the Atherosclerosis Risk in Communities (ARIC) Study, a prospective cohort study of 14,207 adults aged 45 to 64 years, coffee consumption (cups/d) was assessed at a single visit via food frequency questionnaires and compared with incident AKI defined by hospitalization with an AKI-related International Classification of Diseases code. Results: In ARIC, there were 1694 cases of incident AKI in a median of 24 follow-up years. Higher coffee consumption was associated with lower AKI risk versus no consumption (hazard ratio [HR] <1 cup/d: 0.92 [95% CI: 0.79–1.08]; 1 cup/d: 1.08 [95% CI: 0.94–1.24]; 2 to 3 cups/d: 0.83 [95% CI: 0.72–0.95]; >3 cups/d: 0.83 [95% CI: 0.71–0.96]; reference: never, P = 0.003). Trends for AKI risk across coffee categories remained significant after multivariable adjustment for age, sex, race-center, education, total daily energy intake, physical activity, smoking, alcohol intake, diet quality (Dietary Approaches to Stop Hypertension [DASH] score), systolic blood pressure (BP), diabetes status, use of antihypertensive agents, estimated glomerular filtration rate (eGFR), and body mass index (BMI) (P = 0.02). Conclusion: Higher coffee intake was associated with a lower risk of incident AKI and could present an opportunity for cardiorenal protection through diet. Further evaluation of the physiological mechanisms underlying the cardiorenal protective effects of coffee consumption is necessary.",

keywords = "acute kidney injury, beverages, caffeine, coffee, incident AKI",

author = "Tommerdahl, {Kalie L.} and Hu, {Emily A.} and Elizabeth Selvin and Steffen, {Lyn M.} and Josef Coresh and Grams, {Morgan E.} and Petter Bjornstad and Rebholz, {Casey M.} and Parikh, {Chirag R.}",

note = "Funding Information: The authors thank the staff and participants of the ARIC study for their important contributions. The ARIC study has been funded in whole or in part with federal funds from the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Department of Health and Human Services, under contract numbers (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I, HHSN268201700005I). KLT receives salary and research support from the NIH/NHLBI (K23 HL159292), Children's Hospital Colorado Research Institute Research Scholar Award, University of Colorado Diabetes Research Center (P30 DK116073), Ludeman Family Center for Women's Health Research at the University of Colorado, ISPAD-JDRF Research Fellowship, and the Department of Pediatrics, Section of Endocrinology at the University of Colorado School of Medicine. CMR was supported by grants from the NIH/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (K01 DK107782, R03 DK128386) and the NIH/NHLBI (R01 HL153178). ES was supported by the NIH/NHLBI (K24 HL152440). PB receives salary and research support from NIDDK (R01 DK129211, R21 DK129720, K23 DK116720, UC DK114886, and P30 DK116073), JDRF (2-SRA-2019-845-S-B, 3-SRA-2017-424-M-B, 3-SRA-2022-1097-M-B), Boettcher Foundation, American Heart Association (20IPA35260142), Ludeman Family Center for Women's Health Research at the University of Colorado, the Department of Pediatrics, Section of Endocrinology and Barbara Davis Center for Diabetes at University of Colorado School of Medicine. CRP is supported by NIH/NHLBI (R01 HL085757) and NIH/NIDDK (UH3 DK114866, U01 DK106962, R01 DK093770). The funders had no role in the study design; collection, analysis, and interpretation of these data; writing the report; or the decision to submit the report. The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as official policy or interpretation of the US government. Trial Registration:, ClinicalTrials.gov NCT00005131 (ARIC). KLT analyzed and interpreted data and wrote the manuscript. EAH, ES, LMS, JC, and MEG contributed to the development of the research idea and study design. EAH analyzed and interpreted the data. PB and CMR analyzed and interpreted the data and contributed to the discussion. CRP designed the study, analyzed and interpreted the data, and contributed to the discussion. All c-oauthors reviewed and edited the manuscript. CRP and CMR are the guarantor of this work and have full access to the data sets and takes responsibility for the integrity of the data and the accuracy of the data analysis. Funding Information: The authors thank the staff and participants of the ARIC study for their important contributions. The ARIC study has been funded in whole or in part with federal funds from the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Department of Health and Human Services , under contract numbers (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I, HHSN268201700005I). KLT receives salary and research support from the NIH/NHLBI (K23 HL159292), Children{\textquoteright}s Hospital Colorado Research Institute Research Scholar Award, University of Colorado Diabetes Research Center (P30 DK116073), Ludeman Family Center for Women{\textquoteright}s Health Research at the University of Colorado, ISPAD-JDRF Research Fellowship, and the Department of Pediatrics, Section of Endocrinology at the University of Colorado School of Medicine . CMR was supported by grants from the NIH/ National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (K01 DK107782, R03 DK128386) and the NIH/NHLBI (R01 HL153178). ES was supported by the NIH / NHLBI (K24 HL152440). PB receives salary and research support from NIDDK (R01 DK129211, R21 DK129720, K23 DK116720, UC DK114886, and P30 DK116073), JDRF (2-SRA-2019-845-S-B, 3-SRA-2017-424-M-B, 3-SRA-2022-1097-M-B), Boettcher Foundation , American Heart Association (20IPA35260142), Ludeman Family Center for Women{\textquoteright}s Health Research at the University of Colorado , the Department of Pediatrics, Section of Endocrinology and Barbara Davis Center for Diabetes at University of Colorado School of Medicine . CRP is supported by NIH / NHLBI (R01 HL085757) and NIH / NIDDK (UH3 DK114866, U01 DK106962, R01 DK093770). The funders had no role in the study design; collection, analysis, and interpretation of these data; writing the report; or the decision to submit the report. The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as official policy or interpretation of the US government. Trial Registration: Publisher Copyright: {\textcopyright} 2022 International Society of Nephrology",

year = "2022",

month = jul,

doi = "10.1016/j.ekir.2022.04.091",

language = "English (US)",

volume = "7",

pages = "1665--1672",

journal = "Kidney International Reports",

issn = "2468-0249",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - Coffee Consumption May Mitigate the Risk for Acute Kidney Injury

T2 - Results From the Atherosclerosis Risk in Communities Study

AU - Tommerdahl, Kalie L.

AU - Hu, Emily A.

AU - Selvin, Elizabeth

AU - Steffen, Lyn M.

AU - Coresh, Josef

AU - Grams, Morgan E.

AU - Bjornstad, Petter

AU - Rebholz, Casey M.

AU - Parikh, Chirag R.

N1 - Funding Information: The authors thank the staff and participants of the ARIC study for their important contributions. The ARIC study has been funded in whole or in part with federal funds from the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Department of Health and Human Services, under contract numbers (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I, HHSN268201700005I). KLT receives salary and research support from the NIH/NHLBI (K23 HL159292), Children's Hospital Colorado Research Institute Research Scholar Award, University of Colorado Diabetes Research Center (P30 DK116073), Ludeman Family Center for Women's Health Research at the University of Colorado, ISPAD-JDRF Research Fellowship, and the Department of Pediatrics, Section of Endocrinology at the University of Colorado School of Medicine. CMR was supported by grants from the NIH/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (K01 DK107782, R03 DK128386) and the NIH/NHLBI (R01 HL153178). ES was supported by the NIH/NHLBI (K24 HL152440). PB receives salary and research support from NIDDK (R01 DK129211, R21 DK129720, K23 DK116720, UC DK114886, and P30 DK116073), JDRF (2-SRA-2019-845-S-B, 3-SRA-2017-424-M-B, 3-SRA-2022-1097-M-B), Boettcher Foundation, American Heart Association (20IPA35260142), Ludeman Family Center for Women's Health Research at the University of Colorado, the Department of Pediatrics, Section of Endocrinology and Barbara Davis Center for Diabetes at University of Colorado School of Medicine. CRP is supported by NIH/NHLBI (R01 HL085757) and NIH/NIDDK (UH3 DK114866, U01 DK106962, R01 DK093770). The funders had no role in the study design; collection, analysis, and interpretation of these data; writing the report; or the decision to submit the report. The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as official policy or interpretation of the US government. Trial Registration:, ClinicalTrials.gov NCT00005131 (ARIC). KLT analyzed and interpreted data and wrote the manuscript. EAH, ES, LMS, JC, and MEG contributed to the development of the research idea and study design. EAH analyzed and interpreted the data. PB and CMR analyzed and interpreted the data and contributed to the discussion. CRP designed the study, analyzed and interpreted the data, and contributed to the discussion. All c-oauthors reviewed and edited the manuscript. CRP and CMR are the guarantor of this work and have full access to the data sets and takes responsibility for the integrity of the data and the accuracy of the data analysis. Funding Information: The authors thank the staff and participants of the ARIC study for their important contributions. The ARIC study has been funded in whole or in part with federal funds from the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Department of Health and Human Services , under contract numbers (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I, HHSN268201700005I). KLT receives salary and research support from the NIH/NHLBI (K23 HL159292), Children’s Hospital Colorado Research Institute Research Scholar Award, University of Colorado Diabetes Research Center (P30 DK116073), Ludeman Family Center for Women’s Health Research at the University of Colorado, ISPAD-JDRF Research Fellowship, and the Department of Pediatrics, Section of Endocrinology at the University of Colorado School of Medicine . CMR was supported by grants from the NIH/ National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (K01 DK107782, R03 DK128386) and the NIH/NHLBI (R01 HL153178). ES was supported by the NIH / NHLBI (K24 HL152440). PB receives salary and research support from NIDDK (R01 DK129211, R21 DK129720, K23 DK116720, UC DK114886, and P30 DK116073), JDRF (2-SRA-2019-845-S-B, 3-SRA-2017-424-M-B, 3-SRA-2022-1097-M-B), Boettcher Foundation , American Heart Association (20IPA35260142), Ludeman Family Center for Women’s Health Research at the University of Colorado , the Department of Pediatrics, Section of Endocrinology and Barbara Davis Center for Diabetes at University of Colorado School of Medicine . CRP is supported by NIH / NHLBI (R01 HL085757) and NIH / NIDDK (UH3 DK114866, U01 DK106962, R01 DK093770). The funders had no role in the study design; collection, analysis, and interpretation of these data; writing the report; or the decision to submit the report. The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as official policy or interpretation of the US government. Trial Registration: Publisher Copyright: © 2022 International Society of Nephrology

PY - 2022/7

Y1 - 2022/7

N2 - Introduction: Coffee is one of the most frequently consumed beverages worldwide and has been found to have a wide assortment of health benefits. Although habitual coffee consumption is associated with a lower incidence of chronic kidney disease, an association between coffee and acute kidney injury (AKI) has not yet been revealed. Methods: In the Atherosclerosis Risk in Communities (ARIC) Study, a prospective cohort study of 14,207 adults aged 45 to 64 years, coffee consumption (cups/d) was assessed at a single visit via food frequency questionnaires and compared with incident AKI defined by hospitalization with an AKI-related International Classification of Diseases code. Results: In ARIC, there were 1694 cases of incident AKI in a median of 24 follow-up years. Higher coffee consumption was associated with lower AKI risk versus no consumption (hazard ratio [HR] <1 cup/d: 0.92 [95% CI: 0.79–1.08]; 1 cup/d: 1.08 [95% CI: 0.94–1.24]; 2 to 3 cups/d: 0.83 [95% CI: 0.72–0.95]; >3 cups/d: 0.83 [95% CI: 0.71–0.96]; reference: never, P = 0.003). Trends for AKI risk across coffee categories remained significant after multivariable adjustment for age, sex, race-center, education, total daily energy intake, physical activity, smoking, alcohol intake, diet quality (Dietary Approaches to Stop Hypertension [DASH] score), systolic blood pressure (BP), diabetes status, use of antihypertensive agents, estimated glomerular filtration rate (eGFR), and body mass index (BMI) (P = 0.02). Conclusion: Higher coffee intake was associated with a lower risk of incident AKI and could present an opportunity for cardiorenal protection through diet. Further evaluation of the physiological mechanisms underlying the cardiorenal protective effects of coffee consumption is necessary.

AB - Introduction: Coffee is one of the most frequently consumed beverages worldwide and has been found to have a wide assortment of health benefits. Although habitual coffee consumption is associated with a lower incidence of chronic kidney disease, an association between coffee and acute kidney injury (AKI) has not yet been revealed. Methods: In the Atherosclerosis Risk in Communities (ARIC) Study, a prospective cohort study of 14,207 adults aged 45 to 64 years, coffee consumption (cups/d) was assessed at a single visit via food frequency questionnaires and compared with incident AKI defined by hospitalization with an AKI-related International Classification of Diseases code. Results: In ARIC, there were 1694 cases of incident AKI in a median of 24 follow-up years. Higher coffee consumption was associated with lower AKI risk versus no consumption (hazard ratio [HR] <1 cup/d: 0.92 [95% CI: 0.79–1.08]; 1 cup/d: 1.08 [95% CI: 0.94–1.24]; 2 to 3 cups/d: 0.83 [95% CI: 0.72–0.95]; >3 cups/d: 0.83 [95% CI: 0.71–0.96]; reference: never, P = 0.003). Trends for AKI risk across coffee categories remained significant after multivariable adjustment for age, sex, race-center, education, total daily energy intake, physical activity, smoking, alcohol intake, diet quality (Dietary Approaches to Stop Hypertension [DASH] score), systolic blood pressure (BP), diabetes status, use of antihypertensive agents, estimated glomerular filtration rate (eGFR), and body mass index (BMI) (P = 0.02). Conclusion: Higher coffee intake was associated with a lower risk of incident AKI and could present an opportunity for cardiorenal protection through diet. Further evaluation of the physiological mechanisms underlying the cardiorenal protective effects of coffee consumption is necessary.

KW - acute kidney injury

KW - beverages

KW - caffeine

KW - coffee

KW - incident AKI

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UR - http://www.scopus.com/inward/citedby.url?scp=85130494004&partnerID=8YFLogxK

U2 - 10.1016/j.ekir.2022.04.091

DO - 10.1016/j.ekir.2022.04.091

M3 - Article

C2 - 35812301

AN - SCOPUS:85130494004

SN - 2468-0249

VL - 7

SP - 1665

EP - 1672

JO - Kidney International Reports

JF - Kidney International Reports

IS - 7

ER -

Coffee Consumption May Mitigate the Risk for Acute Kidney Injury: Results From the Atherosclerosis Risk in Communities Study

Abstract

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UN SDGs

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