Colloidal stability: Versus self-assembly of nanoparticles controlled by coiled-coil protein interactions

Allison Siehr; Bin Xu; Ronald A. Siegel; Wei Shen

doi:10.1039/c9sm01314h

Colloidal stability: Versus self-assembly of nanoparticles controlled by coiled-coil protein interactions

Allison Siehr, Bin Xu, Ronald A. Siegel, Wei Shen

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Abstract

Orientational discrimination of biomolecular recognition is exploited here as a molecular engineering tool to regulate nanoparticle self-assembly or stability. Nanoparticles are conjugated with the heterodimerizing coiled-coils, A and B, which associate in parallel orientation. Simply flipping the orientation of one coiled-coil results in either self-assembling or colloidally stable nanoparticles.

Original language	English (US)
Pages (from-to)	7122-7126
Number of pages	5
Journal	Soft Matter
Volume	15
Issue number	36
DOIs	https://doi.org/10.1039/c9sm01314h
State	Published - 2019

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© The Royal Society of Chemistry.

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title = "Colloidal stability: Versus self-assembly of nanoparticles controlled by coiled-coil protein interactions",

abstract = "Orientational discrimination of biomolecular recognition is exploited here as a molecular engineering tool to regulate nanoparticle self-assembly or stability. Nanoparticles are conjugated with the heterodimerizing coiled-coils, A and B, which associate in parallel orientation. Simply flipping the orientation of one coiled-coil results in either self-assembling or colloidally stable nanoparticles.",

author = "Allison Siehr and Bin Xu and Siegel, {Ronald A.} and Wei Shen",

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AU - Siehr, Allison

AU - Xu, Bin

AU - Siegel, Ronald A.

AU - Shen, Wei

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PY - 2019

Y1 - 2019

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AB - Orientational discrimination of biomolecular recognition is exploited here as a molecular engineering tool to regulate nanoparticle self-assembly or stability. Nanoparticles are conjugated with the heterodimerizing coiled-coils, A and B, which associate in parallel orientation. Simply flipping the orientation of one coiled-coil results in either self-assembling or colloidally stable nanoparticles.

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Colloidal stability: Versus self-assembly of nanoparticles controlled by coiled-coil protein interactions

Abstract

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