Combination of Clostridium butyricum and Corn Bran Optimized Intestinal Microbial Fermentation Using a Weaned Pig Model

Jie Zhang; Jian Sun; Xiyue Chen; Cunxi Nie; Jinbiao Zhao; Wenyi Guan; Lihui Lei; Ting He; Yiqiang Chen; Lee J. Johnston; Jinshan Zhao; Xi Ma

doi:10.3389/fmicb.2018.03091

Combination of Clostridium butyricum and Corn Bran Optimized Intestinal Microbial Fermentation Using a Weaned Pig Model

Jie Zhang, Jian Sun, Xiyue Chen, Cunxi Nie, Jinbiao Zhao, Wenyi Guan, Lihui Lei, Ting He, Yiqiang Chen, Lee J. Johnston, Jinshan Zhao, Xi Ma

West Central Research and Outreach Center

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Experimental manipulation of the intestinal microbiota influences health of the host and is a common application for synbiotics. Here Clostridium butyricum (C. butyricum, C.B) combined with corn bran (C.B + Bran) was taken as the synbiotics application in a waned pig model to investigate its regulation of intestinal health over 28 days postweaning. Growth performance, fecal short chain fatty acids (SCFAs) and bacterial community were evaluated at day 14 and day 28 of the trial. Although the C.B + Bran treatment has no significant effects on growth performance (P > 0.05), it optimized the composition of intestinal bacteria, mainly represented by increased acetate-producing bacteria and decreased pathogens. Microbial fermentation in the intestine showed a shift from low acetate and isovalerate production on day 14 to enhanced acetate production on day 28 in the C.B + Bran treatment. Thus, C.B and corn bran promoted intestinal microbial fermentation and optimized the microbial community for pigs at an early age. These findings provide perspectives on the advantages of synbiotics as a new approach for effective utilization of corn barn.

Original language	English (US)
Article number	3091
Journal	Frontiers in Microbiology
Volume	9
DOIs	https://doi.org/10.3389/fmicb.2018.03091
State	Published - Mar 29 2018

Bibliographical note

Funding Information:
This work was supported by the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Natural Science Foundation of China (31829004, 31722054, and 31472101), the College of Animal Science and Technology “Young Talents Program” at China Agricultural University (2017DKA001), the Beijing Nova Programme Interdisciplinary Cooperation Project (xxjc201804), the 111 Project (B16044), the Developmental Fund for Animal Science by Shenzhen Jinxinnong Feed Co., Ltd., and the Apply Basic Research Project in Xinjiang Production and Construction Crops of

Publisher Copyright:
© Copyright © 2018 Zhang, Sun, Chen, Nie, Zhao, Guan, Lei, He, Chen, Johnston, Zhao and Ma.

Keywords

Clostridium butyricum
corn bran
intestinal bacteria
short chain fatty acids
synbiotics
weaned pig model

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title = "Combination of Clostridium butyricum and Corn Bran Optimized Intestinal Microbial Fermentation Using a Weaned Pig Model",

abstract = "Experimental manipulation of the intestinal microbiota influences health of the host and is a common application for synbiotics. Here Clostridium butyricum (C. butyricum, C.B) combined with corn bran (C.B + Bran) was taken as the synbiotics application in a waned pig model to investigate its regulation of intestinal health over 28 days postweaning. Growth performance, fecal short chain fatty acids (SCFAs) and bacterial community were evaluated at day 14 and day 28 of the trial. Although the C.B + Bran treatment has no significant effects on growth performance (P > 0.05), it optimized the composition of intestinal bacteria, mainly represented by increased acetate-producing bacteria and decreased pathogens. Microbial fermentation in the intestine showed a shift from low acetate and isovalerate production on day 14 to enhanced acetate production on day 28 in the C.B + Bran treatment. Thus, C.B and corn bran promoted intestinal microbial fermentation and optimized the microbial community for pigs at an early age. These findings provide perspectives on the advantages of synbiotics as a new approach for effective utilization of corn barn.",

keywords = "Clostridium butyricum, corn bran, intestinal bacteria, short chain fatty acids, synbiotics, weaned pig model",

author = "Jie Zhang and Jian Sun and Xiyue Chen and Cunxi Nie and Jinbiao Zhao and Wenyi Guan and Lihui Lei and Ting He and Yiqiang Chen and Johnston, {Lee J.} and Jinshan Zhao and Xi Ma",

note = "Funding Information: This work was supported by the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Natural Science Foundation of China (31829004, 31722054, and 31472101), the College of Animal Science and Technology “Young Talents Program” at China Agricultural University (2017DKA001), the Beijing Nova Programme Interdisciplinary Cooperation Project (xxjc201804), the 111 Project (B16044), the Developmental Fund for Animal Science by Shenzhen Jinxinnong Feed Co., Ltd., and the Apply Basic Research Project in Xinjiang Production and Construction Crops of Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2018 Zhang, Sun, Chen, Nie, Zhao, Guan, Lei, He, Chen, Johnston, Zhao and Ma.",

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AU - Chen, Xiyue

AU - Nie, Cunxi

AU - Zhao, Jinbiao

AU - Guan, Wenyi

AU - Lei, Lihui

AU - He, Ting

AU - Chen, Yiqiang

AU - Johnston, Lee J.

AU - Zhao, Jinshan

AU - Ma, Xi

N1 - Funding Information: This work was supported by the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Natural Science Foundation of China (31829004, 31722054, and 31472101), the College of Animal Science and Technology “Young Talents Program” at China Agricultural University (2017DKA001), the Beijing Nova Programme Interdisciplinary Cooperation Project (xxjc201804), the 111 Project (B16044), the Developmental Fund for Animal Science by Shenzhen Jinxinnong Feed Co., Ltd., and the Apply Basic Research Project in Xinjiang Production and Construction Crops of Publisher Copyright: © Copyright © 2018 Zhang, Sun, Chen, Nie, Zhao, Guan, Lei, He, Chen, Johnston, Zhao and Ma.

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N2 - Experimental manipulation of the intestinal microbiota influences health of the host and is a common application for synbiotics. Here Clostridium butyricum (C. butyricum, C.B) combined with corn bran (C.B + Bran) was taken as the synbiotics application in a waned pig model to investigate its regulation of intestinal health over 28 days postweaning. Growth performance, fecal short chain fatty acids (SCFAs) and bacterial community were evaluated at day 14 and day 28 of the trial. Although the C.B + Bran treatment has no significant effects on growth performance (P > 0.05), it optimized the composition of intestinal bacteria, mainly represented by increased acetate-producing bacteria and decreased pathogens. Microbial fermentation in the intestine showed a shift from low acetate and isovalerate production on day 14 to enhanced acetate production on day 28 in the C.B + Bran treatment. Thus, C.B and corn bran promoted intestinal microbial fermentation and optimized the microbial community for pigs at an early age. These findings provide perspectives on the advantages of synbiotics as a new approach for effective utilization of corn barn.

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Combination of Clostridium butyricum and Corn Bran Optimized Intestinal Microbial Fermentation Using a Weaned Pig Model

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