Combined measurement of plasma cell proliferative and apoptotic index in multiple myeloma defines patients with good and poor prognosis

Jiri Minarik; Vlastimil Scudla; Marta Ordeltova; Tomas Pika; Jaroslav Bacovsky; Michael Steinbach; Vipin Kumar; Brian Van Ness

doi:10.1016/j.leukres.2010.04.015

Combined measurement of plasma cell proliferative and apoptotic index in multiple myeloma defines patients with good and poor prognosis

Jiri Minarik, Vlastimil Scudla, Marta Ordeltova, Tomas Pika, Jaroslav Bacovsky, Michael Steinbach, Vipin Kumar, Brian Van Ness

Research output: Contribution to journal › Article › peer-review

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Abstract

We assessed plasma cell proliferation (by propidium iodide index, PC-PI) and apoptosis (by annexin-V index PC-AI) for the estimation of overall survival (OS) in multiple myeloma (MM) patients. 181 patients with newly diagnosed MM were assessed, treated using conventional chemotherapy. The values best discriminating patients with poor prognosis were PC-PI. > 3.0% and PC-AI. < 4.75%, and for good prognosis PC-PI. ≤ 3.0% and PC-AI. ≥ 4.75%. The median OS was 8 months vs 40 months, p = 0.0002.Our results suggest that combined measurement of plasma cell proliferation and apoptosis creates a unique strong prognostic factor based on growth characteristics of the tumor clone.

Original language	English (US)
Pages (from-to)	44-48
Number of pages	5
Journal	Leukemia research
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2010.04.015
State	Published - Jan 2011

Bibliographical note

Funding Information:
The study was supported by the grants of Ministry of Health of the Czech Republic (NR 9500-3 and 9489-3 ).

Keywords

Apoptosis
Multiple myeloma
Prognosis
Proliferation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{af21e1fc522848a4bc9602cf71860265,

title = "Combined measurement of plasma cell proliferative and apoptotic index in multiple myeloma defines patients with good and poor prognosis",

abstract = "We assessed plasma cell proliferation (by propidium iodide index, PC-PI) and apoptosis (by annexin-V index PC-AI) for the estimation of overall survival (OS) in multiple myeloma (MM) patients. 181 patients with newly diagnosed MM were assessed, treated using conventional chemotherapy. The values best discriminating patients with poor prognosis were PC-PI. > 3.0% and PC-AI. < 4.75%, and for good prognosis PC-PI. ≤ 3.0% and PC-AI. ≥ 4.75%. The median OS was 8 months vs 40 months, p = 0.0002.Our results suggest that combined measurement of plasma cell proliferation and apoptosis creates a unique strong prognostic factor based on growth characteristics of the tumor clone.",

keywords = "Apoptosis, Multiple myeloma, Prognosis, Proliferation",

author = "Jiri Minarik and Vlastimil Scudla and Marta Ordeltova and Tomas Pika and Jaroslav Bacovsky and Michael Steinbach and Vipin Kumar and {Van Ness}, Brian",

note = "Funding Information: The study was supported by the grants of Ministry of Health of the Czech Republic (NR 9500-3 and 9489-3 ).",

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doi = "10.1016/j.leukres.2010.04.015",

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AU - Minarik, Jiri

AU - Scudla, Vlastimil

AU - Ordeltova, Marta

AU - Pika, Tomas

AU - Bacovsky, Jaroslav

AU - Steinbach, Michael

AU - Kumar, Vipin

AU - Van Ness, Brian

N1 - Funding Information: The study was supported by the grants of Ministry of Health of the Czech Republic (NR 9500-3 and 9489-3 ).

PY - 2011/1

Y1 - 2011/1

N2 - We assessed plasma cell proliferation (by propidium iodide index, PC-PI) and apoptosis (by annexin-V index PC-AI) for the estimation of overall survival (OS) in multiple myeloma (MM) patients. 181 patients with newly diagnosed MM were assessed, treated using conventional chemotherapy. The values best discriminating patients with poor prognosis were PC-PI. > 3.0% and PC-AI. < 4.75%, and for good prognosis PC-PI. ≤ 3.0% and PC-AI. ≥ 4.75%. The median OS was 8 months vs 40 months, p = 0.0002.Our results suggest that combined measurement of plasma cell proliferation and apoptosis creates a unique strong prognostic factor based on growth characteristics of the tumor clone.

AB - We assessed plasma cell proliferation (by propidium iodide index, PC-PI) and apoptosis (by annexin-V index PC-AI) for the estimation of overall survival (OS) in multiple myeloma (MM) patients. 181 patients with newly diagnosed MM were assessed, treated using conventional chemotherapy. The values best discriminating patients with poor prognosis were PC-PI. > 3.0% and PC-AI. < 4.75%, and for good prognosis PC-PI. ≤ 3.0% and PC-AI. ≥ 4.75%. The median OS was 8 months vs 40 months, p = 0.0002.Our results suggest that combined measurement of plasma cell proliferation and apoptosis creates a unique strong prognostic factor based on growth characteristics of the tumor clone.

KW - Apoptosis

KW - Multiple myeloma

KW - Prognosis

KW - Proliferation

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JF - Leukemia research

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Combined measurement of plasma cell proliferative and apoptotic index in multiple myeloma defines patients with good and poor prognosis

Abstract

Bibliographical note

Keywords

UN SDGs

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