Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease

Jinghong Kou; Min Song; Abhinandan Pattanayak; Jeong Eun Lim; Junling Yang; Dongfeng Cao; Ling Li; Ken ichiro Fukuchi

doi:10.1016/j.jneuroim.2012.01.008

Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease

Jinghong Kou, Min Song, Abhinandan Pattanayak, Jeong Eun Lim, Junling Yang, Dongfeng Cao, Ling Li, Ken ichiro Fukuchi

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We evaluated the therapeutic efficacy of combined treatment of Aβ-immunization with simvastatin in an Alzheimer mouse model at age 22. months. DNA prime-adenovirus boost immunization induced modest anti-Aβ titers and simvastatin increased the seropositive rate. Aβ-KLH was additionally administered to boost the titers. Irrespective of simvastatin, the immunization did not decrease cerebral Aβ deposits but increased soluble Aβ and tended to exacerbate amyloid angiopathy in the hippocampus. The immunization increased cerebral invasion of leukocytes and simvastatin counteracted the increase. Thus, modest anti-Aβ titers can increase soluble Aβ and simvastatin may reduce inflammation associated with vaccination in aged Alzheimer mouse models.

Original language	English (US)
Pages (from-to)	70-83
Number of pages	14
Journal	Journal of Neuroimmunology
Volume	244
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2012.01.008
State	Published - Mar 2012

Bibliographical note

Funding Information:
We thank Linda Walter for assistance in preparation of this manuscript. This research was supported in part by grants from the National Institutes of Health ( AG031846 , AG031979 , AG037814 , AG030399 , AG029818 and EY018478 ) and the Alzheimer's Association ( IIRG-07-59494 ).

Keywords

Adenovirus
Alzheimer's disease
Amyloid
Inflammation
Statin
Vaccine

Access

10.1016/j.jneuroim.2012.01.008

OpenUrl availability

Full text

Cite this

@article{90a0f2d6e89641c1ae17e3505484f0d9,

title = "Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease",

abstract = "We evaluated the therapeutic efficacy of combined treatment of Aβ-immunization with simvastatin in an Alzheimer mouse model at age 22. months. DNA prime-adenovirus boost immunization induced modest anti-Aβ titers and simvastatin increased the seropositive rate. Aβ-KLH was additionally administered to boost the titers. Irrespective of simvastatin, the immunization did not decrease cerebral Aβ deposits but increased soluble Aβ and tended to exacerbate amyloid angiopathy in the hippocampus. The immunization increased cerebral invasion of leukocytes and simvastatin counteracted the increase. Thus, modest anti-Aβ titers can increase soluble Aβ and simvastatin may reduce inflammation associated with vaccination in aged Alzheimer mouse models.",

keywords = "Adenovirus, Alzheimer's disease, Amyloid, Inflammation, Statin, Vaccine",

author = "Jinghong Kou and Min Song and Abhinandan Pattanayak and Lim, {Jeong Eun} and Junling Yang and Dongfeng Cao and Ling Li and Fukuchi, {Ken ichiro}",

note = "Funding Information: We thank Linda Walter for assistance in preparation of this manuscript. This research was supported in part by grants from the National Institutes of Health ( AG031846 , AG031979 , AG037814 , AG030399 , AG029818 and EY018478 ) and the Alzheimer's Association ( IIRG-07-59494 ).",

year = "2012",

month = mar,

doi = "10.1016/j.jneuroim.2012.01.008",

language = "English (US)",

volume = "244",

pages = "70--83",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease

AU - Kou, Jinghong

AU - Song, Min

AU - Pattanayak, Abhinandan

AU - Lim, Jeong Eun

AU - Yang, Junling

AU - Cao, Dongfeng

AU - Li, Ling

AU - Fukuchi, Ken ichiro

N1 - Funding Information: We thank Linda Walter for assistance in preparation of this manuscript. This research was supported in part by grants from the National Institutes of Health ( AG031846 , AG031979 , AG037814 , AG030399 , AG029818 and EY018478 ) and the Alzheimer's Association ( IIRG-07-59494 ).

PY - 2012/3

Y1 - 2012/3

N2 - We evaluated the therapeutic efficacy of combined treatment of Aβ-immunization with simvastatin in an Alzheimer mouse model at age 22. months. DNA prime-adenovirus boost immunization induced modest anti-Aβ titers and simvastatin increased the seropositive rate. Aβ-KLH was additionally administered to boost the titers. Irrespective of simvastatin, the immunization did not decrease cerebral Aβ deposits but increased soluble Aβ and tended to exacerbate amyloid angiopathy in the hippocampus. The immunization increased cerebral invasion of leukocytes and simvastatin counteracted the increase. Thus, modest anti-Aβ titers can increase soluble Aβ and simvastatin may reduce inflammation associated with vaccination in aged Alzheimer mouse models.

AB - We evaluated the therapeutic efficacy of combined treatment of Aβ-immunization with simvastatin in an Alzheimer mouse model at age 22. months. DNA prime-adenovirus boost immunization induced modest anti-Aβ titers and simvastatin increased the seropositive rate. Aβ-KLH was additionally administered to boost the titers. Irrespective of simvastatin, the immunization did not decrease cerebral Aβ deposits but increased soluble Aβ and tended to exacerbate amyloid angiopathy in the hippocampus. The immunization increased cerebral invasion of leukocytes and simvastatin counteracted the increase. Thus, modest anti-Aβ titers can increase soluble Aβ and simvastatin may reduce inflammation associated with vaccination in aged Alzheimer mouse models.

KW - Adenovirus

KW - Alzheimer's disease

KW - Amyloid

KW - Inflammation

KW - Statin

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=84862813698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862813698&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2012.01.008

DO - 10.1016/j.jneuroim.2012.01.008

M3 - Article

C2 - 22326143

AN - SCOPUS:84862813698

SN - 0165-5728

VL - 244

SP - 70

EP - 83

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this