Comparison of Peripheral Blast Clearance and Day 14 Bone Marrow Biopsy in Predicting Remission Status and Survival After 7+3 Induction in Acute Myeloid Leukemia

Fahrettin Covut; Divya Gupta; Raisa Pinto; Nina Dambrosio; Najla El Jurdi; Howard Meyerson; Masumi Ueda; Merle Kolk; Richard Creger; Leland Metheny; Brenda W. Cooper; Paolo F. Caimi; Ehsan Malek; Folashade Otegbeye; Hillard M. Lazarus; Marcos De Lima; Benjamin K. Tomlinson

doi:10.1016/j.clml.2018.11.001

Comparison of Peripheral Blast Clearance and Day 14 Bone Marrow Biopsy in Predicting Remission Status and Survival After 7+3 Induction in Acute Myeloid Leukemia

Fahrettin Covut, Divya Gupta, Raisa Pinto, Nina Dambrosio, Najla El Jurdi, Howard Meyerson, Masumi Ueda, Merle Kolk, Richard Creger, Leland Metheny, Brenda W. Cooper, Paolo F. Caimi, Ehsan Malek, Folashade Otegbeye, Hillard M. Lazarus, Marcos De Lima, Benjamin K. Tomlinson

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Abstract

Early identification of acute myeloid leukemia patients with persistent disease after cytarabine and an anthracycline (7+3) induction is crucial to improve outcome. In the present retrospective study we analyzed the previously described methods to predict outcome of induction. Rapid clearance of peripheral blasts and day 14 bone marrow biopsy provided additional prognostic value over existing prognostic factors.

Original language	English (US)
Pages (from-to)	73-82
Number of pages	10
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.clml.2018.11.001
State	Published - Feb 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

AML
Complete remission
Day 14 bone marrow
Peripheral blast disappearance
Prognosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Covut, F., Gupta, D., Pinto, R., Dambrosio, N., El Jurdi, N., Meyerson, H., Ueda, M., Kolk, M., Creger, R., Metheny, L., Cooper, B. W., Caimi, P. F., Malek, E., Otegbeye, F., Lazarus, H. M., De Lima, M., & Tomlinson, B. K. (2019). Comparison of Peripheral Blast Clearance and Day 14 Bone Marrow Biopsy in Predicting Remission Status and Survival After 7+3 Induction in Acute Myeloid Leukemia. Clinical Lymphoma, Myeloma and Leukemia, 19(2), 73-82. https://doi.org/10.1016/j.clml.2018.11.001

Covut, F, Gupta, D, Pinto, R, Dambrosio, N, El Jurdi, N, Meyerson, H, Ueda, M, Kolk, M, Creger, R, Metheny, L, Cooper, BW, Caimi, PF, Malek, E, Otegbeye, F, Lazarus, HM, De Lima, M & Tomlinson, BK 2019, 'Comparison of Peripheral Blast Clearance and Day 14 Bone Marrow Biopsy in Predicting Remission Status and Survival After 7+3 Induction in Acute Myeloid Leukemia', Clinical Lymphoma, Myeloma and Leukemia, vol. 19, no. 2, pp. 73-82. https://doi.org/10.1016/j.clml.2018.11.001

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abstract = "Early identification of acute myeloid leukemia patients with persistent disease after cytarabine and an anthracycline (7+3) induction is crucial to improve outcome. In the present retrospective study we analyzed the previously described methods to predict outcome of induction. Rapid clearance of peripheral blasts and day 14 bone marrow biopsy provided additional prognostic value over existing prognostic factors.",

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year = "2019",

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doi = "10.1016/j.clml.2018.11.001",

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AU - Gupta, Divya

AU - Pinto, Raisa

AU - Dambrosio, Nina

AU - El Jurdi, Najla

AU - Meyerson, Howard

AU - Ueda, Masumi

AU - Kolk, Merle

AU - Creger, Richard

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AU - Cooper, Brenda W.

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AU - Lazarus, Hillard M.

AU - De Lima, Marcos

AU - Tomlinson, Benjamin K.

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KW - Complete remission

KW - Day 14 bone marrow

KW - Peripheral blast disappearance

KW - Prognosis

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Comparison of Peripheral Blast Clearance and Day 14 Bone Marrow Biopsy in Predicting Remission Status and Survival After 7+3 Induction in Acute Myeloid Leukemia

Abstract

Bibliographical note

Keywords

UN SDGs

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