Abstract
The cytotoxicity of 5-thio-D-glucose (5-TG) and misonidazole (MISO) on hypoxic cells in vitro was compared, and the combined effect of these two compounds was investigated. The cytotoxicity of 5-TG on hypoxic SCK mammary carcinoma cells of mice was markedly greater than that of MISO. However, MISO was more toxic than was 5-TG to P815-X2 mastocytoma cells of mice. The elevation of temperature from 37.5°C to 40.0°C during incubation with drugs greatly enhanced the cell death. The thermal enhancement of cytotoxicity of 5-TG to mastocytoma cells appeared to be greater than that of MISO. Preliminary studies indicated that the combined effect of 5-TG and MISO is additive, suggesting the intracellular targets or cytocidal mechanisms of these two compounds may be different.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 749-752 |
| Number of pages | 4 |
| Journal | International Journal of Radiation Oncology, Biology, Physics |
| Volume | 8 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - 1982 |
Bibliographical note
Funding Information:This work was supported by a grant (#CA 2 I28 1) awarded by the NCI. Reprint requests to: C.vV. Song, Ph.D., University of Minnesota, Department of Therapeutic Radiology, Box 494 Mayo Hospital, Minneapolis, MN 55455. Presented at the CROS Conference on Chemical Modifica-
Keywords
- 5-Thio-D-glucose
- Hypoxic cells
- Misonidazole
