Abstract
A 20-min venous occlusion and a desmopressin acetate (DDAVP, 0.4 μg.Kg-1, 15 min) infusion test have been compared to evaluate fibrinolytic capacity in proven coronary artery disease. Basal values of plasma tissue plasminogen activator (t-PA)activity and antigen and of t-PA inhibitor (PAI) were normally distributed in this patient group. However, after both stimuli, highly signficant (P < 0.005) increases of t-PA antigen and activity have been observed. Renormalization of t-PA levels after DDAVP infusion occurred more rapidly for antigen (120 min) than for activity concentrations (> 240 min). A DDAVP infusion test seems more appropriate for evaluation of the fibrinolytic capacity as the induced decrease in PAI level was significant (P < 0.005) and lasted for at least 240 min, while it was not significant for the venous occlusion test.
Original language | English (US) |
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Pages (from-to) | 800-802 |
Number of pages | 3 |
Journal | European heart journal |
Volume | 12 |
Issue number | 7 |
State | Published - 1991 |
Keywords
- Coronary artery disease
- Desmopressin
- Fibrinolysis
- Venous occlusion