Abstract
We discuss the importance of mathematical modeling in synthetic biology. We present the essential elements of the Synthetic Biology Software Suite (SynBioSS) and discuss the experimental construction and testing of two synthetic biological devices as guided by SynBioSS. In addition, we discuss the computer-aided design of logical-AND gates and of protein devices in bacteria. © 2013
Original language | English (US) |
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Title of host publication | Synthetic Biology |
Publisher | Elsevier Inc. |
Pages | 123-139 |
Number of pages | 17 |
ISBN (Print) | 9780123944306 |
DOIs | |
State | Published - 2013 |
Bibliographical note
Funding Information:This work was supported by a grant from the National Institutes of Health (American Recovery and Reinvestment Act grant GM086865) and a grant from the National Science Foundation (CBET-0644792). Partial funding for this work was also provided through a grant from the Synthetic Ecology Program of the Biotechnology Institute and from the Presidential Initiative on Biocatalysis at the University of Minnesota.
Keywords
- Computer-aided design
- Multiscale models
- Protein devices
- Synthetic biological networks